Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jun;153(3):449-456.
doi: 10.1002/ijgo.13661. Epub 2021 Mar 28.

Maternal and neonatal outcomes of pregnant patients with COVID-19: A prospective cohort study

Masoumeh Abedzadeh-Kalahroudi  1 , Mojtaba Sehat  2 , Zahra Vahedpour  3 , Parisa Talebian  4
Affiliations

Maternal and neonatal outcomes of pregnant patients with COVID-19: A prospective cohort study

Masoumeh Abedzadeh-Kalahroudi et al. Int J Gynaecol Obstet. 2021 Jun.

Abstract

Objective: To determine the maternal and neonatal outcomes of pregnant women with COVID-19 infection.

Methods: A cohort study was conducted on 56 pregnant women with COVID-19 and 94 healthy pregnant women during the COVID-19 epidemic in Iran. Two groups were followed until childbirth. Demographic and obstetric information, clinical symptoms, laboratory and radiographic findings of the patients, and maternal and neonatal outcomes of the two groups were gathered by a checklist. Data were analyzed using SPSS version 16. A P value < 0.05 was considered significant.

Results: The two groups were similar in terms of maternal age, gravida, parity, and co-morbidities (P > 0.05). The rate of cesarean delivery in the exposed group was higher than that in the control group (P = 0.027; relative risk [RR] =2.23). Pre-eclampsia was seen in 19.8% of the exposed group and 7.4% of the control group (P = 0.037; RR = 2.68). The rate of preterm labor in the exposed group was higher than that in the control group (P = 0.003; RR = 2.70). Fetal distress was seen in 16.1% of the exposed group and 4.3% of the control group (P = 0.016; RR = 3.84).

Conclusion: Pregnant women with COVID-19 had an increased risk of pre-eclampsia, preterm labor, and cesarean delivery. Their fetal and neonatal outcomes were fetal distress, newborn prematurity, and low Apgar score.

Keywords: COVID-19; maternal; neonatal; outcome; pregnancy.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest.

References

    1. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2019;2020(395):497‐506. - PMC - PubMed
    1. Sahin D, Tanacan A, Erol SA, et al. A pandemic center’s experience of managing pregnant women with COVID‐19 infection in Turkey: a prospective cohort study. Int J Gynecol Obstetr. 2020;151(1):74‐82. - PMC - PubMed
    1. Knight M, Bunch K, Vousden N, et al. Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS‐CoV‐2 infection in UK: national population based cohort study. BMJ. 2020;369:m2107. - PMC - PubMed
    1. Fan C, Lei D, Fang C, et al. Perinatal transmission of COVID‐19 associated SARS‐CoV‐2: should we worry? Clin Infect Dis. 2020; 10.1093/cid/ciaa226 - DOI - PMC - PubMed
    1. Rasmussen SA, Smulian JC, Lednicky JA, Wen TS, Jamieson DJ. Coronavirus Disease 2019 (COVID‐19) and pregnancy: what obstetricians need to know. Am J Obstet Gynecol. 2020;222(5):415‐426. - PMC - PubMed