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. 2021 Dec 16;73(12):2322-2325.
doi: 10.1093/cid/ciab180.

Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever

Natalie Lorenz  1   2 , Timothy K C Ho  1 , Reuben McGregor  1   2 , Mark R Davies  3 , Deborah A Williamson  3 , Jason K Gurney  4 , Pierre R Smeesters  5 , Michael G Baker  2   4 , Nicole J Moreland  1   2
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Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever

Natalie Lorenz et al. Clin Infect Dis. .

Erratum in

Abstract

Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.

Keywords: emm-cluster; emm-type; group A Streptococcus; immune priming; rheumatic fever.

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