. 2021 Dec 16;73(12):2322-2325.

doi: 10.1093/cid/ciab180.

Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever

Natalie Lorenz^{1

2}, Timothy K C Ho¹, Reuben McGregor^{1

2}, Mark R Davies³, Deborah A Williamson³, Jason K Gurney⁴, Pierre R Smeesters⁵, Michael G Baker^{2

4}, Nicole J Moreland^{1

2}

Affiliations

¹ School of Medical Sciences, University of Auckland, Auckland, New Zealand.
² Maurice Wilkins Centre for Biodiscovery, Auckland, New Zealand.
³ Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia.
⁴ Department of Public Health, University of Otago, Wellington, New Zealand.
⁵ Molecular Bacteriology Laboratory, Université Libre de Bruxelles, Brussels, Belgium.

PMID: 33639619
DOI: 10.1093/cid/ciab180

Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever

Natalie Lorenz et al. Clin Infect Dis. 2021.

. 2021 Dec 16;73(12):2322-2325.

doi: 10.1093/cid/ciab180.

Authors

Natalie Lorenz^{1

2}, Timothy K C Ho¹, Reuben McGregor^{1

2}, Mark R Davies³, Deborah A Williamson³, Jason K Gurney⁴, Pierre R Smeesters⁵, Michael G Baker^{2

4}, Nicole J Moreland^{1

2}

Affiliations

¹ School of Medical Sciences, University of Auckland, Auckland, New Zealand.
² Maurice Wilkins Centre for Biodiscovery, Auckland, New Zealand.
³ Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia.
⁴ Department of Public Health, University of Otago, Wellington, New Zealand.
⁵ Molecular Bacteriology Laboratory, Université Libre de Bruxelles, Brussels, Belgium.

PMID: 33639619
DOI: 10.1093/cid/ciab180

Erratum in

Correction to: Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever.
Campbell BN. Campbell BN. Clin Infect Dis. 2023 Mar 4;76(5):973. doi: 10.1093/cid/ciac307. Clin Infect Dis. 2023. PMID: 36702615 No abstract available.

Abstract

Rheumatic fever is a serious post-infectious sequela of group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.

Keywords: emm-cluster; emm-type; group A Streptococcus; immune priming; rheumatic fever.

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Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever

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Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever

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