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Comparative Study
. 2021 Feb 28;21(1):32.
doi: 10.1186/s12894-021-00802-x.

Comparative assessment of biodegradable-antireflux heparine coated ureteral stent: animal model study

Federico Soria  1 , Julia E de La Cruz  2 , Juan Pablo Caballero-Romeu  3 , Manuel Pamplona  4 , Daniel Pérez-Fentes  5 , Luis Resel-Folskerma  6 , Francisco M Sanchez-Margallo  7
Affiliations
Comparative Study

Comparative assessment of biodegradable-antireflux heparine coated ureteral stent: animal model study

Federico Soria et al. BMC Urol. .

Abstract

Background: Double J ureteral stents are widely used on urological patients to provide drainage of the upper urinary tract. Unfourtunately, ureteral stents are not free from complications, as bacterial colonization and require a second procedure for removal. The purpose of the current comparative experimental study is to evaluate a new heparin-coated biodegradable antireflux ureteral stent (BraidStent®-H) to prevent urinary bacterial colonization.

Methods: A total of 24 female pigs were underwent determination of bacteriuria and nephrosonographic, endoscopic and contrast fluoroscopy assessment of the urinary tract. Afterward, were randomly assigned animals to Group-I, in which a 5Fr double-pigtail ureteral stent was placed for 6 weeks, or Group-II, in which a BraidStent®-H was placed. Follow-up assessments were performed at 1, 3, 6, 8, 12 weeks. The final follow-up includes the above methods and an exhaustive pathological study of the urinary tract was accomplished after 20 weeks.

Results: Bacteriuria findings in the first 48 h were significant between groups at 6 h and 12 h. Asymptomatic bacteriuria does not reach 100% of the animals in Group-II until 48 h versus Group-I where it appears at 6 h. The weekly bacteriuria mean rate was 27.7% and 44.4% in Group I and II respectively, without statistical significance. In Group II there were no animals with vesicoureteral reflux, with statistical significance at 3 and 6 weeks with Group-I. The 91.2% of stents in Group-II were degraded between 3 and 6 weeks, without obstructive fragments. Distal ureteral peristalsis was maintained in 66.6-75% in Group-II at 1-6 weeks.

Conclusions: The heparin coating of BraidStent® allows an early decrease of bacterial colonization, but its effectiveness is low at the long term. Heparin coating did not affect scheduled degradation rate or size of stents fragments. BraidStent®-H avoids the side effects associated with current ureteral stents, thus should cause less discomfort to patients.

Keywords: Antireflux stents; Biodegradable ureteral stent; Biofilm; Heparin coated; Morbidity.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Illustration of the BraidStent®-H in upper urinary tract
Fig. 2
Fig. 2
Cystoscopic view of the floating tiny BraidStent®-H fragments at 6 weeks
See this image and copyright information in PMC

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