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Review
. 2022 Mar;314(2):133-140.
doi: 10.1007/s00403-021-02207-0. Epub 2021 Feb 28.

Macrophages in dermatology: pathogenic roles and targeted therapeutics

Drew Kuraitis  1 , Nadia Rosenthal  2   3 , Erin Boh  4 , Elizabeth McBurney  4
Affiliations
Review

Macrophages in dermatology: pathogenic roles and targeted therapeutics

Drew Kuraitis et al. Arch Dermatol Res. 2022 Mar.

Abstract

The field of macrophage biology is rapidly growing. Recent studies have shifted focus from classic wound healing roles to newly identified roles in dermatologic pathology. These studies have identified pathogenic roles of macrophages in relatively common conditions, such as psoriasis, skin cancer, and cutaneous T-cell lymphoma. Selective depletion of these cells or their associated cytokines leads to improved clinical outcome. Herein, we review recent animal and human studies that have elucidated novel pathogenic roles of macrophages in conditions frequently encountered by dermatologists and discuss clinically relevant macrophage-targeted therapies.

Keywords: Cutaneous T-cell lymphoma; Immunology; Macrophage; Melanoma; Monocyte; Psoriasis; Skin cancer.

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References

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