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. 2021 Mar;37(2):147-152.
doi: 10.1007/s12055-020-01061-5. Epub 2020 Nov 7.

Investigation of serum ischemia-modified albumin levels in coronary artery disease patients

Mustafa Etli  1
Affiliations

Investigation of serum ischemia-modified albumin levels in coronary artery disease patients

Mustafa Etli. Indian J Thorac Cardiovasc Surg. 2021 Mar.

Abstract

Objective: Ischemia-modified albumin (IMA) is a novel marker for the detection of ischemia. The value of this biomarker has been studied in patients with coronary artery disease (CAD). However, the relationship between the severity of coronary stenosis and serum IMA levels remains unknown. Therefore, we aimed to investigate the potential role of serum IMA levels in predicting the severity of coronary atherosclerosis.

Materials and methods: One hundred and forty-two individuals who underwent coronary angiography for coronary artery disease complaints were included in the study. Participants were divided into three groups based on their diagnosis as control (healthy subjects), group I (subjects with lower Gensini score), and group II (subjects with higher Gensini score). Global Registry of Acute Coronary Events (GRACE) risk score and Gensini scores were calculated after coronary angiogram in the patient groups. Then, venous blood samples were collected from each participant. Serum IMA levels and the levels of routine laboratory markers were measured.

Results: The serum lymphocyte, neutrophil, and high-density lipid (HDL) levels were statistically insignificant between the groups. The white blood cell (WBC) count and IMA levels were significantly higher in the patient groups (p < 0.05). The GRACE and Gensini scores were significantly different in the patient groups (p < 0.05). However, there was no significant correlation between the GRACE and Gensini scores and serum IMA levels.

Conclusion: Although IMA levels can be a significant predictor for ischemia according to previous reports, this biomarker seems to be insufficient for determining the severity of disease in patients with CAD.

Keywords: Cardiovascular disease; Coronary artery disease; Disease severity.

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Conflict of interest statement

Conflict of interestThe authors declare that they have no conflict of interest.

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References

    1. Bar-Or D, Lau E, Winkler JV. A novel assay for cobalt–albumin binding and its potential as a marker for myocardial ischemia -- a preliminary report. J Emerg Med. 2000;19:311–315. doi: 10.1016/S0736-4679(00)00255-9. - DOI - PubMed
    1. Caliskan A, Yavuz C, Karahan O, et al. Serum ischaemia-modified albumin level is an irrelevant predictive factor for ischaemic duration in mesenteric ischaemia. Perfusion. 2014;29:226–230. doi: 10.1177/0267659113505640. - DOI - PubMed
    1. Gaze DC. Ischemia modified albumin: a novel biomarker for the detection of cardiac ischemia. Drug Metab Pharmacokinet. 2009;24:333–341. doi: 10.2133/dmpk.24.333. - DOI - PubMed
    1. Talwalkar SS, Bon Homme M, Miller JJ, Elin RJ. Ischemia modified albumin, a marker of acute ischemic events: a pilot study. Ann Clin Lab Sci. 2008;38:132–137. - PubMed
    1. Shepard D, VanderZanden A, Moran A, Naghavi M, Murray C, Roth G. Ischemic heart disease worldwide, 1990 to 2013: estimates from the Global Burden of Disease Study 2013. Circ Cardiovasc Qual Outcomes. 2015;8:455–456. doi: 10.1161/CIRCOUTCOMES.115.002007. - DOI - PMC - PubMed

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