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. 2021 Jan-Feb;25(1):47-54.
doi: 10.4103/jisp.jisp_45_20. Epub 2020 Sep 21.

Association between nonalcoholic fatty liver disease and inflammatory periodontal disease: A case‑control study

Ajay Duseja  1 , Gurparkash Singh Chahal  2 , Ashish Jain  2 , Manu Mehta  1 , Aditya Ranjan  2 , Vishakha Grover  2
Affiliations

Association between nonalcoholic fatty liver disease and inflammatory periodontal disease: A case‑control study

Ajay Duseja et al. J Indian Soc Periodontol. 2021 Jan-Feb.

Abstract

Background: Recent evidence suggests an interconnection between chronic periodontal disease and systemic diseases.

Aim: The aim of this study is to evaluate the possible association between nonalcoholic fatty liver disease (NAFLD) and inflammatory periodontal disease among north Indian population.

Settings and design: Tertiary health care center, cross-sectional case-control observational study.

Materials and methods: A total of 40 cases, i.e., patients with NAFLD and 40 healthy volunteers were included over a period of 8 months and their periodontal status was compared. The status of their hepatic health was ascertained by anthropometric, imaging, and biochemical evaluation including ultrasound examination of abdomen and transient elastography.

Statistical data analysis: Paired t-test, multivariate logistic regression analysis using IBM SPSS STATISTICS (version 22.0, Armonk, NY: IBM Corp).

Results: The study revealed that only 11.9% and 20% of participants had periodontitis, in healthy controls and hepatic disease patients, respectively. A statistically significant difference was observed in clinical parameters of periodontal status, except for malocclusion. Comparative analysis of tumor necrosis factor-α (TNF-α), interleukin-6, C-reactive protein, and cytokeratin-18 revealed differences in mean scores, though statistically nonsignificant. Only aspartate transaminase, number of missing teeth, and bleeding on probing (BOP) were observed with higher odds ratios for hepatic disease patients. Spearman correlation analysis revealed significant positive correlations between TNF-α and BOP, for cases.

Conclusion: Patients with hepatic disease showed a higher prevalence of periodontal disease, worse oral hygiene and periodontal health status compared to healthy individuals.

Keywords: Bleeding on probing; case control; nonalcoholic fatty liver disease; oral health; periodontal disease; systemic health; tumor necrosis factor.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Graph showing distribution of study subjects based on anthropologic parameters in NAFLD case group population. NAFLD: Nonalcoholic fatty liver disease; BMI: Body mass index
Figure 2
Figure 2
Graph showing distribution of study subjects based on presence of parameters of metabolic syndrome in NAFLD case group population. NAFLD: Nonalcoholic fatty liver disease
Figure 3
Figure 3
Graph showing correlation between BOP and TNF-α in NAFLD case population. BOP: Bleeding on probing; TNF-α: Tumor necrosis factor-alpha; NAFLD: Nonalcoholic fatty liver disease
See this image and copyright information in PMC

References

    1. Van Dyke TE, van Winkelhoff AJ. Infection and inflammatory mechanisms. J Periodontol. 2013;84:1–7. - PubMed
    1. Grossi SG. Treatment of periodontal disease and control of diabetes: An assessment of evidence and need for future research. Ann Periodontol. 2001;6:138–45. - PubMed
    1. Iacopino AM, Cutler CW. Pathophysiological relationships between periodontitis and systemic disease: Recent concepts involving serum lipids. J Periodontol. 2000;71:1375–84. - PubMed
    1. Klokkevold PR. Periodontal medicine: Assessment of risk factors for disease. J Calif Dent Assoc. 1999;27:135–42. - PubMed
    1. Li X, Kolltveit KM, Tronstad L, Olsen I. Systemic diseases caused by oral infection. Clin Microbiol Rev. 2000;13:547–58. - PMC - PubMed