Pathophysiology and Epidemiology of Diverticular Disease
- PMID: 33642946
- PMCID: PMC7904337
- DOI: 10.1055/s-0040-1716698
Pathophysiology and Epidemiology of Diverticular Disease
Abstract
Diverticular disease exists on a spectrum, ranging from asymptomatic diverticulosis to complicated diverticulitis. Incidence of diverticulitis in western nations has increased in recent years, although the factors that influence the progression from diverticulosis to diverticulitis are unknown. Geographic/environmental influences, lifestyle variables, and microbiota of the gastrointestinal tract are some of the factors implicated in diverticular disease.
Keywords: colon; diverticulitis; diverticulosis; inflammation; microbiome; risk factors.
Thieme. All rights reserved.
Conflict of interest statement
Conflict of Interest None.
References
-
- Ricciardi R, Roberts P L, Read T E. Cyclical increase in diverticulitis during the summer months. Arch Surg. 2011;146(03):319–323. - PubMed
-
- Daniels L, Philipszoon L E, Boermeester M A. A hypothesis: important role for gut microbiota in the etiopathogenesis of diverticular disease. Dis Colon Rectum. 2014;57(04):539–543. - PubMed
-
- Stumpf M, Cao W, Klinge U, Klosterhalfen B, Kasperk R, Schumpelick V. Increased distribution of collagen type III and reduced expression of matrix metalloproteinase 1 in patients with diverticular disease. Int J Colorectal Dis. 2001;16(05):271–275. - PubMed
