Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Feb 15:14:1756284821993581.
doi: 10.1177/1756284821993581. eCollection 2021.

Medical therapies for postoperative Crohn's disease

Ravi S Shah  1 , Benjamin H Click  2
Affiliations
Review

Medical therapies for postoperative Crohn's disease

Ravi S Shah et al. Therap Adv Gastroenterol. .

Abstract

Postoperative recurrence of Crohn's disease is common and requires a multidisciplinary approach between surgeons and gastroenterologists in the perioperative and postoperative period to improve outcomes in this patient population. Endoscopic recurrence precedes clinical and surgical recurrence and endoscopic monitoring is crucial to guide postoperative management. Risk stratification of patients is recommended to guide early prophylactic management, and follow-up endoscopic monitoring can guide intensification of therapy. This review summarizes evidence behind postoperative recurrence rates, disease monitoring techniques, nonbiologic and biologic therapies available to prevent and treat postoperative recurrence, risk factors associated with recurrence, and postoperative management strategies guided by endoscopic monitoring.

Keywords: anti-tumor necrosis factor; postoperative Crohn’s disease.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest statement: The authors declare that there is no conflict of interest.

Figures

Figure 1.
Figure 1.
Proposed management strategies for prevention of POR of CD. CD, Crohn’s disease; POR, postoperative recurrence.
See this image and copyright information in PMC

References

    1. Bernstein CN, Loftus EV, Jr, Ng SC, et al. Hospitalisations and surgery in Crohn’s disease. Gut 2012; 61: 622–629. - PubMed
    1. Nguyen GC, Nugent Z, Shaw S, et al. Outcomes of patients with Crohn’s disease improved from 1988 to 2008 and were associated with increased specialist care. Gastroenterology 2011; 141: 90–97. - PubMed
    1. Vind I, Riis L, Jess T, et al. Increasing incidences of inflammatory bowel disease and decreasing surgery rates in Copenhagen city and county, 2003–2005: a population-based study from the Danish Crohn colitis database. Am J Gastroenterol 2006; 101: 1274–1282. - PubMed
    1. Ramadas AV, Gunesh S, Thomas GAO, et al. Natural history of Crohn’s disease in a population-based cohort from Cardiff (1986–2003): a study of changes in medical treatment and surgical resection rates. Gut 2010; 59: 1200–1206. - PubMed
    1. Murthy SK, Begum J, Benchimol EI, et al. Introduction of anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases: a population-based interrupted time series study. Gut 2020; 69: 274–282. - PMC - PubMed

LinkOut - more resources