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Review
. 2021 Feb 26;9(6):1251-1258.
doi: 10.12998/wjcc.v9.i6.1251.

Animal models of cathartic colon

Yang-Yang Meng  1 , Qiao-Dong Li  1 , Ya Feng  1 , Jie Liu  1 , En-Kang Wang  1 , Linda Zhong  1 , Qiao-Li Sun  1 , Jian-Ye Yuan  2
Affiliations
Review

Animal models of cathartic colon

Yang-Yang Meng et al. World J Clin Cases. .

Abstract

The incidence of cathartic colon has been increasing, but satisfactory treatments are still lacking. In order to study the pathological mechanisms of the disorder and identify effective treatment methods, researchers have established different animal models of cathartic colon. This minireview briefly summarizes several common cathartic colon animal models, induced with anthraquinone laxatives such as rhubarb, total anthraquinone, rhein, and emodin, or induced with diphenylmethane laxatives such as phenolphthalein. The advantages and limitations of these models are evaluated and analyzed. We hope that this review will facilitate the selection of suitable models and improve relevant modeling methods. We anticipate the development of more convenient and stable models that can reflect the characteristics of cathartic colon in humans, and serve as useful tools for further studies.

Keywords: Animal model; Anthraquinones; Cathartic colon; Constipation; Diphenylmethane; Laxative.

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Conflict of interest statement

Conflict-of-interest statement: There is no conflict of interest to report.

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