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. 1988 Apr;295(4):275-9.
doi: 10.1097/00000441-198804000-00010.

Renal microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid

L Lapuerta  1 , N Chacos, J R Falck, H Jacobson, J H Capdevila
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Renal microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid

L Lapuerta et al. Am J Med Sci. 1988 Apr.

Abstract

Arachidonic acid is oxidized by the microsomal cytochrome P-450 monooxygenases of rabbit kidney cortex and medulla to products that include W and W-1 alcohols and several epoxyacids. In vivo administration of deoxycorticosterone acetate results in a time dependent and selective induction of the arachidonic acid W/W-1 oxygenase activity of cortex and medulla microsomal fractions (145% and 220% of controls, respectively). Initial segmental analysis shows the presence of an active epoxygenase activity in the isolated rabbit pars recta and its in vitro activation by p-aminohippuric acid.

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