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. 2021 Apr 13;325(14):1467-1469.
doi: 10.1001/jama.2021.3341.

Binding and Neutralization Antibody Titers After a Single Vaccine Dose in Health Care Workers Previously Infected With SARS-CoV-2

Saman Saadat  1 , Zahra Rikhtegaran Tehrani  1 , James Logue  2 , Michelle Newman  3 , Matthew B Frieman  2 , Anthony D Harris  3 , Mohammad M Sajadi  1
Affiliations

Binding and Neutralization Antibody Titers After a Single Vaccine Dose in Health Care Workers Previously Infected With SARS-CoV-2

Saman Saadat et al. JAMA. .

Abstract

This study compares titers of binding and neutralizing antibodies after a single mRNA coronavirus vaccine dose in health care workers previously infected with SARS-CoV-2.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Harris reported receiving grants from CDC Covid Supplement during the conduct of the study. No other disclosures were reported.

Figures

Figure.
Figure.. Anti–SARS-CoV-2 Antibody Responses After a Single Dose of Vaccine in Health Care Workers
After COVID-19 vaccination, plasma was drawn at 0, 7, and 14 days; IgG binding titers against spike trimer were measured by enzyme-linked immunosorbent assay and live virus neutralization was assessed at days 0 and 14. A, IgG spike trimer half-maximal titers. By 7 days and continuing through 14 days following vaccination, both groups of health care workers with prior infection (asymptomatic and symptomatic) who received a single vaccine dose developed higher peak IgG titers than the antibody (Ab)-negative group. B, Live virus neutralization ID99 (the 99% inhibitory dose, the dilution at which 99% of cells were protected). At 14 days, both groups of health care workers with prior infection (asymptomatic and symptomatic) who received a single vaccine dose developed higher neutralization titers than the Ab-negative group. Horizontal black lines represent median values.
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