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Meta-Analysis
. 2021 Mar 1;16(3):e0247143.
doi: 10.1371/journal.pone.0247143. eCollection 2021.

Subjective caregiver burden and anxiety in informal caregivers: A systematic review and meta-analysis

Rafael Del-Pino-Casado  1 , Emilia Priego-Cubero  1 , Catalina López-Martínez  1 , Vasiliki Orgeta  2
Affiliations
Meta-Analysis

Subjective caregiver burden and anxiety in informal caregivers: A systematic review and meta-analysis

Rafael Del-Pino-Casado et al. PLoS One. .

Abstract

There is increasing evidence that subjective caregiver burden is an important determinant of clinically significant anxiety in family carers. This meta-analysis aims to synthesise this evidence and investigate the relationship between subjective caregiver burden and anxiety symptoms in informal caregivers. We searched PubMed, CINAHL and PsycINFO up to January 2020. Combined estimates were obtained using a random-effects model. After screening of 4,312 articles, 74 studies (with 75 independent samples) were included. There was a large, positive association between subjective caregiver burden and anxiety symptoms (r = 0.51; 95% CI = 0.47, 0.54; I2 = 0.0%). No differences were found in subgroup analyses by type of study design (cross-sectional vs. longitudinal), sampling, control of confounders or care-recipient characteristics. Subjective caregiver burden is an important risk factor for anxiety in informal caregivers. Targeting subjective caregiver burden could be beneficial in preventing clinically significant anxiety for the increasing number of family carers worldwide.

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Conflict of interest statement

The first author was the chief investigator of two studies meeting inclusion criteria for this review. This does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no other known conflicts of interest.

Figures

Fig 1
Fig 1. Flow diagram (PRISMA).
Fig 2
Fig 2. Forest plot of the results of the meta-analysis.
Fig 3
Fig 3. Funnel plot of the results of the meta-analysis.
See this image and copyright information in PMC

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