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. 2022 Aug;57(8):1904-1913.
doi: 10.1002/ppul.25320. Epub 2021 Mar 1.

Clinical validation of a mandibular movement signal based system for the diagnosis of pediatric sleep apnea

Jean-Benoit Martinot  1   2 , Valérie Cuthbert  1 , Nhat N Le-Dong  3 , Nathalie Coumans  1 , Deborah De Marneffe  1 , Clément Letesson  3 , Jean L Pépin  4 , David Gozal  5   6
Affiliations

Clinical validation of a mandibular movement signal based system for the diagnosis of pediatric sleep apnea

Jean-Benoit Martinot et al. Pediatr Pulmonol. 2022 Aug.

Abstract

Background: Given the high prevalence and risk for outcomes associated with pediatric obstructive sleep apnea (OSA), there is a need for simplified diagnostic approaches. A prospective study in 140 children undergoing in-laboratory polysomnography (PSG) evaluates the accuracy of a recently developed system (Sunrise) to estimate respiratory efforts by monitoring sleep mandibular movements (MM) for the diagnosis of OSA (Sunrise™).

Methods: Diagnosis and severity were defined by an obstructive apnea/hypopnea index (OAHI) ≥ 1 (mild), ≥ 5 (moderate), and ≥ 10 events/h (severe). Agreement between PSG and Sunrise™ was assessed by Bland-Altman method comparing respiratory disturbances hourly index (RDI) (obstructive apneas, hypopneas, and respiratory effort-related arousals) during PSG (PSG_RDI), and Sunrise RDI (Sr_RDI). Performance of Sr_RDI was determined via ROC curves evaluating the device sensitivity and specificity at PSG_OAHI ≥ 1, 5, and 15 events/h.

Results: A median difference of 1.57 events/h, 95% confidence interval: -2.49 to 8.11 was found between Sr_RDI and PSG_RDI. Areas under the ROC curves of Sr_RDI were 0.75 (interquartile range [IQR]: 0.72-0.78), 0.90 (IQR: 0.86-0.92) and 0.95 (IQR: 0.90-0.99) for detecting children with PSG_OAHI ≥ 1, PSG_OAHI ≥ 5, or PSG_ OAHI ≥ 10, respectively.

Conclusion: MM automated analysis shows significant promise to diagnose moderate-to-severe pediatric OSA.

Keywords: machine learning; mandibular movement; pediatric obstructive sleep apnea.

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References

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