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Multicenter Study
. 2021 Sep-Oct:24:100338.
doi: 10.1016/j.aohep.2021.100338. Epub 2021 Feb 26.

Lactate-dehydrogenase associated with mortality in hospitalized patients with COVID-19 in Mexico: a multi-centre retrospective cohort study

Paulina Vidal-Cevallos  1 , Fatima Higuera-De-La-Tijera  2 , Norberto C Chávez-Tapia  3 , Francisco Sanchez-Giron  4 , Eira Cerda-Reyes  5 , Victor Hugo Rosales-Salyano  6 , Alfredo Servin-Caamaño  6 , Martín Uriel Vázquez-Medina  7 , Nahum Méndez-Sánchez  8
Affiliations
Multicenter Study

Lactate-dehydrogenase associated with mortality in hospitalized patients with COVID-19 in Mexico: a multi-centre retrospective cohort study

Paulina Vidal-Cevallos et al. Ann Hepatol. 2021 Sep-Oct.

Abstract

Introduction and objectives: As of January 2021, over 88 million people have been infected with COVID-19. Almost two million people have died of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A high SOFA score and a D-Dimer >1 µg/mL identifies patients with high risk of mortality. High lactate dehydrogenase (LDH) levels on admission are associated with severity and mortality. Different degrees of alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) abnormalities have been reported in these patients, its association with a mortality risk remains controversial. The aim of this study was to explore the correlation between LDH and in-hospital mortality in Mexican patients admitted with COVID-19.

Materials & methods: We performed a retrospective multi-centre cohort study with 377 hospitalized patients with confirmed SARS-CoV-2 in three centres in Mexico City, Mexico, who were ≥18 years old and died or were discharged between April 1 and May 31, 2020.

Results: A total of 377 patients were evaluated, 298 (79.1%) patients were discharged, and 79 (20.9%) patients died during hospitalization. Non-survivors were older, with a median age of 46.7 ± 25.7 years old, most patients were male. An ALT > 61 U/l (OR 3.45, 95% CI 1.27-9.37; p = 0.015), C-reactive protein (CRP) > 231 mg/l (OR 4.71, 95% CI 2.35-9.46; p = 0.000), LDH > 561 U/l (OR 3.03, 95% CI 1.40-6.55; p = 0.005) were associated with higher odds for in-hospital death.

Conclusions: Our results indicate that higher levels of LDH, CRP, and ALT are associated with higher in-hospital mortality risk in Mexican patients admitted with COVID-19.

Keywords: Biochemical markers; Mortality determinants; Pandemics.; Retrospective studies; Severe acute respiratory syndrome coronavirus 2.

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Figures

Fig. 1
Fig. 1
Flowchart of study population.
Fig. 2
Fig. 2
Difference in proportion of patients with alterations in ALT (alanine aminotransferase), CRP (C reactive protein), and LDH (lactate dehydrogenase) between survivors and non-survivors.
See this image and copyright information in PMC

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References

    1. Lu R., Zhao X., Li J., Niu P., Yang B., Wu H., et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet [Internet] 2020;395(10224):565–574. doi: 10.1016/S0140-6736(20)30251-8. - DOI - PMC - PubMed
    1. Wu C., Chen X., Cai Y., Xia J., Zhou X., Xu S., et al. Risk Factors Associated with Acute Respiratory Distress Syndrome and Death in Patients with Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med. 2020;180(7):934–943. - PMC - PubMed
    1. Zhou F., Yu T., Du R., Fan G., Liu Y., Liu Z., et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet [Internet]. 2020;395(10229):1054–1062. https://linkinghub.elsevier.com/retrieve/pii/S0140673620305663. - PMC - PubMed
    1. Li X., Xu S., Yu M., Wang K., Tao Y., Zhou Y. 2020. Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. - PMC - PubMed
    1. Saklayen M.G. The global epidemic of the metabolic syndrome. Curr Hypertens Rep [Internet] 2018;20(2):12. http://link.springer.com/10.1007/s11906-018-0812-z - DOI - PMC - PubMed

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