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Review
. 2021 Apr:220:153385.
doi: 10.1016/j.prp.2021.153385. Epub 2021 Feb 16.

BCYRN1: An oncogenic lncRNA in diverse cancers

Soudeh Ghafouri-Fard  1 , Sepideh Dashti  1 , Bashdar Mahmud Hussen  2 , Molood Farsi  3 , Mohammad Taheri  4
Affiliations
Review

BCYRN1: An oncogenic lncRNA in diverse cancers

Soudeh Ghafouri-Fard et al. Pathol Res Pract. 2021 Apr.

Abstract

Brain cytoplasmic 200 (BC200) or alternatively named as brain cytoplasmic RNA 1 (BCYRN1) is a long non-coding RNA (lncRNA) primarily identified in the neurons. In addition to its participation in the pathogenesis of neurodegenerative disorders, it partake in the carcinogenesis process. Numerous in vitro studies have reported elevation of expression of BCYRN1 in cancer cell lines. Short hairpin-RNA-mediated silencing of BCYRN1 has attenuated growth of tumors in the animal models. Independent studies in esophageal squamous cell cancer, gastric cancer, colorectal cancer, hepatocellular carcinoma and non-small cell lung cancer have demonstrated association between elevated BCYRN1 levels and poor survival of patients. Taken together, BCYRN1 is an appropriate candidate for targeted therapies in the field of cancer.

Keywords: BC200; BCYRN1; Cancer; lncRNA.

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