Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Mar 1;19(1):22.
doi: 10.1186/s12969-021-00493-6.

Juvenile primary Fibromyalgia Syndrome: epidemiology, etiology, pathogenesis, clinical manifestations and diagnosis

Maya Levy Coles  1 , Rotem Weissmann  1 , Yosef Uziel  2   3
Affiliations
Review

Juvenile primary Fibromyalgia Syndrome: epidemiology, etiology, pathogenesis, clinical manifestations and diagnosis

Maya Levy Coles et al. Pediatr Rheumatol Online J. .

Abstract

Juvenile primary fibromyalgia syndrome (JPFS) is a chronic, musculoskeletal pain syndrome affecting children and adolescents, most commonly adolescent girls. The syndrome has a multifactorial etiology, with altered central pain processing playing an important role. The hallmark symptom is severe, widespread musculoskeletal pain. Other symptoms include sleep and mood disturbances, headaches, stiffness, and subjective joint swelling. Physical examination can reveal multiple tender points. The diagnosis is clinical, with defined criteria. Early diagnosis and intervention are important. In this part of the review, we discuss the epidemiology, etiology, pathogenesis, clinical manifestations and diagnosis of JPFS. Part two will focus on treatment and prognosis.

Keywords: Chronic pain; Fibromyalgia; JPFS; Juvenile; Musculoskeletal pain syndrome.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

References

    1. Weiss JE, Stinson JN. Pediatric Pain syndromes and noninflammaitory Musculoskeletal Pain. Pediatr Clin north am. 2018;65(4):801–26 10.1016/j.pcl.2018.04.004. - PubMed
    1. Weissmann R, Uziel Y. Pediatric complex regional pain syndrome: a review. Pediatr Rheumatol Online J. 2016;14(1):29. doi: 10.1186/s12969-016-0090-8. - DOI - PMC - PubMed
    1. Yunus MB, Masi AT. Juvenile primary fibromyalgia syndrome. A clinical study of thirty-three patients and matched normal controls. Arthritis Rheum. 1985;28(2):138–145. doi: 10.1002/art.1780280205. - DOI - PubMed
    1. Queiroz LP. Worldwide epidemiology of Fibromyalgia. Curr Pain Headache Rep. 2013;17(8):356. doi: 10.1007/s11916-013-0356-5. - DOI - PubMed
    1. Clark P, Burgos-Vargas R, Medina-Palma C, Lavielle P, Marina FF. Prevalence of fibromyalgia in children: a clinical study of Mexican children. J Rheumatol. 1998;25(10):2009–2014. - PubMed