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Review
. 2021 Apr;16(2):249-260.
doi: 10.1016/j.cpet.2020.12.009.

Tau Imaging in Head Injury

Cyrus Ayubcha  1 , Mateen Moghbel  2 , Austin J Borja  3 , Andrew Newberg  4 , Thomas J Werner  5 , Abass Alavi  5 , Mona-Elisabeth Revheim  6
Affiliations
Free article
Review

Tau Imaging in Head Injury

Cyrus Ayubcha et al. PET Clin. 2021 Apr.
Free article

Abstract

Tau proteins play a significant role in a variety of degenerative neurologic conditions. Postmortem neuropathology studies of victims of repeat and severe head trauma have defined a unique spatial expression of neurologic tauopathies in these individuals, known as chronic traumatic encephalopathy. Established and newly developed radiotracers are now being applied to head injury populations with the intent of diagnosis and disease monitoring. This review assesses the role of tau in head injury, the state of tau radiotracer development, and the potential clinical value of tau-PET as derived from head injury studies.

Keywords: CTE; Chronic traumatic encephalopathy; Imaging; Neurodegeneration; PET; Tau.

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Conflict of interest statement

Conflict of interest The authors have declared no conflicts of interest. Disclosure The authors have nothing to disclose.

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