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. 2021 Feb 1;31(1):17-21.
doi: 10.1684/ejd.2021.3973.

Review of the European Society for Photodynamic Therapy (Euro-PDT) Annual Congress 2020

Colin A Morton  1 , Rolf-Markus Szeimies  2 , Lasse R Braathen  3
Affiliations

Review of the European Society for Photodynamic Therapy (Euro-PDT) Annual Congress 2020

Colin A Morton et al. Eur J Dermatol. .

Abstract

This article reviews the 2020 European Society for Photodynamic Therapy (Euro-PDT) Annual Congress. Cutting edge studies included assessment of immunohistochemical variables influencing response of basal cell carcinomas and Bowen's disease to PDT with p53, the only biomarker associated with good response in both conditions. A further study indicated that analysis of molecular markers, such as PIK3R1, could help select patients with actinic keratoses who demonstrate the best response to daylight PDT. Novel delivery protocols include artificial daylight, and laser-assisted and textile PDT. The meeting learnt of novel indications including antimicrobial PDT, as well as methods to optimise daylight PDT, including combination therapy for actinic keratoses. Adverse events were reviewed and options for painless and efficient PDT assessed, including the effect of reduced drug-light interval. A smartphone application was also evaluated which may be used to assist clinicians and patients in effective dosing and timing of daylight PDT via computational algorithms using data from earth observation satellites, to send light and ultraviolet dose information directly to patients' smart phones.

Keywords: actinic keratoses; biomarkers; daylight; dosimetry; non-melanoma skin cancer; photodynamic therapy.

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References

    1. Morton CA, Szeimies R-M, Basset-Seguin N, et al. European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 1: treatment delivery and established indications — actinic keratoses. Bowen’s disease and basal cell carcinomas. 1. J Eur Acad Dermatol Venereol. 2019;33:2225–38. doi: 10.1111/jdv.16017. - DOI - PubMed
    1. Morton CA, Szeimies R-M, Basset-Seguin N, et al. European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 2: emerging indications — field cancerization, photo-rejuvenation and inflammatory/infective dermatoses. J Eur Acad Dermatol Venereol. 2020;34:17–29. doi: 10.1111/jdv.16044. - DOI - PubMed
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