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Comment
. 2021 Mar;9(3):254.
doi: 10.1158/2326-6066.CIR-21-0026.

How to Reprogram Myeloma-Associated Macrophages: Target IKZF1

Francesco De Sanctis  1 , Vincenzo Bronte  2
Affiliations
Comment

How to Reprogram Myeloma-Associated Macrophages: Target IKZF1

Francesco De Sanctis et al. Cancer Immunol Res. 2021 Mar.

Abstract

Cancer cells hijack tumor-associated macrophages to sustain their outgrowth. In this issue, Mougiakakos and colleagues identify the IKZF1-IRF4/IRF5 axis as a key molecular pathway regulating macrophage polarization in multiple myeloma. These results suggest targeting IKZF1 could provide a new strategy to reprogram myeloma-associated macrophages toward a tumoricidal and immune-activating phenotype.See article by Mougiakakos et al., p. 265.

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  • The IKZF1-IRF4/IRF5 Axis Controls Polarization of Myeloma-Associated Macrophages.
    Mougiakakos D, Bach C, Böttcher M, Beier F, Röhner L, Stoll A, Rehli M, Gebhard C, Lischer C, Eberhardt M, Vera J, Büttner-Herold M, Bitterer K, Balzer H, Leffler M, Jitschin S, Hundemer M, Awwad MHS, Busch M, Stenger S, Völkl S, Schütz C, Krönke J, Mackensen A, Bruns H. Mougiakakos D, et al. Cancer Immunol Res. 2021 Mar;9(3):265-278. doi: 10.1158/2326-6066.CIR-20-0555. Epub 2021 Feb 9. Cancer Immunol Res. 2021. PMID: 33563611

References

    1. Ugel S, De Sanctis F, Mandruzzato S, Bronte V. Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages. J Clin Invest. 2015;125:3365–76.
    1. Kumar SK, Rajkumar V, Kyle RA, van Duin M, Sonneveld P, Mateos MV, et al. Multiple myeloma. Nat Rev Dis Primers. 2017;3:17046.
    1. Mougiakakos D, Bach C, Böttcher M, Beier F, Röhner L, Stoll A, et al. The IKZF1–IRF4/IRF5 axis controls polarization of myeloma-associated macrophages. Cancer Immunol Res. 2021;9:265–78.
    1. Han JW, Zheng HF, Cui Y, Sun LD, Ye DQ, Hu Z, et al. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet. 2009;41:1234–7.

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