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Comment
. 2021 Mar 1;6(1):99.
doi: 10.1038/s41392-021-00498-3.

D614G and SARS-CoV-2 replication fitness

Kathleen D Engelman  1 , Alan N Engelman  2   3
Affiliations
Comment

D614G and SARS-CoV-2 replication fitness

Kathleen D Engelman et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

K.D.E. declares no competing interests. A.N.E. has consulted for ViiV Healthcare Co. and received compensation on unrelated work.

Figures

Fig. 1
Fig. 1
D614G and SARS-CoV-2 transmissibility. The G614 virus variant (left) replicates more efficiently than the ancestral D614 virus in tissues of the upper respiratory epithelium. The higher density of S protein trimers on the viral surface as well as the frequency of spikes in the open receptor-binding configuration may contribute to increased transmission of the D614G mutant virus
See this image and copyright information in PMC

Comment on

  • Spike mutation D614G alters SARS-CoV-2 fitness.
    Plante JA, Liu Y, Liu J, Xia H, Johnson BA, Lokugamage KG, Zhang X, Muruato AE, Zou J, Fontes-Garfias CR, Mirchandani D, Scharton D, Bilello JP, Ku Z, An Z, Kalveram B, Freiberg AN, Menachery VD, Xie X, Plante KS, Weaver SC, Shi PY. Plante JA, et al. Nature. 2021 Apr;592(7852):116-121. doi: 10.1038/s41586-020-2895-3. Epub 2020 Oct 26. Nature. 2021. PMID: 33106671 Free PMC article.

References

    1. Plante, J. A. et al. Spike mutation D614G alters SARS-CoV-2 fitness. Nature (2020) in press. - PMC - PubMed
    1. Korber B, et al. Tracking changes in SARS-CoV-2 spike: Evidence that D614G increases infectivity of the COVID-19 virus. Cell. 2020;182:812–827.e19. doi: 10.1016/j.cell.2020.06.043. - DOI - PMC - PubMed
    1. Hou YJ, et al. SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo. Science. 2020;370:1464–1468. - PMC - PubMed
    1. Yurkovetskiy L, et al. Structural and functional analysis of the D614G SARS-CoV-2 spike protein variant. Cell. 2020;183:739–751.e8. doi: 10.1016/j.cell.2020.09.032. - DOI - PMC - PubMed
    1. Zhang L, et al. SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity. Nat. Commun. 2020;11:6013. doi: 10.1038/s41467-020-19808-4. - DOI - PMC - PubMed

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