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Comment
. 2021 Mar 1;6(1):101.
doi: 10.1038/s41392-021-00502-w.

Mutation D614G increases SARS-CoV-2 transmission

Prerna Arora  1   2 , Stefan Pöhlmann  3   4 , Markus Hoffmann  5   6
Affiliations
Comment

Mutation D614G increases SARS-CoV-2 transmission

Prerna Arora et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Mutation D614G in the SARS-CoV-2 spike protein augments transmission. Viruses with the amino acid substitution D614G show increased replication capacity in the human nasal epithelium but not small and large airways ex vivo. Replication of G614 virus in the nasal epithelium of experimentally inoculated hamsters was not increased but the G614 virus was transmitted faster to recipient animals as compared to the D614 virus
See this image and copyright information in PMC

Comment on

  • SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo.
    Hou YJ, Chiba S, Halfmann P, Ehre C, Kuroda M, Dinnon KH 3rd, Leist SR, Schäfer A, Nakajima N, Takahashi K, Lee RE, Mascenik TM, Graham R, Edwards CE, Tse LV, Okuda K, Markmann AJ, Bartelt L, de Silva A, Margolis DM, Boucher RC, Randell SH, Suzuki T, Gralinski LE, Kawaoka Y, Baric RS. Hou YJ, et al. Science. 2020 Dec 18;370(6523):1464-1468. doi: 10.1126/science.abe8499. Epub 2020 Nov 12. Science. 2020. PMID: 33184236 Free PMC article.

References

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    1. Plante, J. A. et al. Spike mutation D614G alters SARS-CoV-2 fitness. Nature (2020) 10.1038/s41586-020-2895-3. Online ahead of print. - PMC - PubMed

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