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. 2021 May;21(5):269-271.
doi: 10.1038/s41577-021-00523-0.

Decoding bat immunity: the need for a coordinated research approach

Affiliations

Decoding bat immunity: the need for a coordinated research approach

Lin-Fa Wang et al. Nat Rev Immunol. 2021 May.

Abstract

Understanding antiviral immune responses in bats, which are reservoirs for many emerging viruses, could aid the response to future epidemics. Here, we discuss five key areas in which greater consensus among the bat research community is necessary to drive breakthroughs in the field.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Key areas for consensus in bat immunology.
a | Key technical competencies necessary to advance understanding of bat immunity. At the top of the pyramid are competencies that will only be feasible to establish for a limited number of species and for which the importance of consensus increases. b | Five major bat species proposed for captive breeding colony establishment and in vivo model development.

References

    1. Teeling EC, et al. Bat biology, genomes, and the Bat1K project: to generate chromosome-level genomes for all living bat species. Annu. Rev. Anim. Biosci. 2018;6:23–46. doi: 10.1146/annurev-animal-022516-022811. - DOI - PubMed
    1. Letko M, Seifert SN, Olival KJ, Plowright RK, Munster VJ. Bat-borne virus diversity, spillover and emergence. Nat. Rev. Microbiol. 2020;18:461–471. doi: 10.1038/s41579-020-0394-z. - DOI - PMC - PubMed
    1. Irving AT, Ahn M, Goh G, Anderson DE, Wang L-F. Lessons from the host defences of bats, a unique viral reservoir. Nature. 2021;589:363–370. doi: 10.1038/s41586-020-03128-0. - DOI - PubMed
    1. Mollentze N, Streicker DG. Viral zoonotic risk is homogenous among taxonomic orders of mammalian and avian reservoir hosts. Proc. Natl Acad. Sci. USA. 2020;117:9423–9430. doi: 10.1073/pnas.1919176117. - DOI - PMC - PubMed
    1. Ahn M, et al. Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host. Nat. Microbiol. 2019;4:789–799. doi: 10.1038/s41564-019-0371-3. - DOI - PMC - PubMed

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