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. 2020 Oct;9(3):270-277.
doi: 10.29252/rbmb.9.3.270.

Assessment the Correlations of Hormones, Lipid Profiles, Oxidative Stress, and Zinc Concentration in Iraqi Women with Polycystic Ovary Syndrome

Ashwaq Shenta  1 , Khansaa Saud  1 , Ali Al-Shawi  1
Affiliations

Assessment the Correlations of Hormones, Lipid Profiles, Oxidative Stress, and Zinc Concentration in Iraqi Women with Polycystic Ovary Syndrome

Ashwaq Shenta et al. Rep Biochem Mol Biol. 2020 Oct.

Abstract

Background: Polycystic ovary syndrome (PCOS) is a hormonal disorder in women with unknown causes and is the leading cause of infertility in women of reproductive age, presenting a wide range of clinical manifestations worldwide. The objective of study is to compare the correlation between hormones, lipid profile, oxidative stress and Zinc concentration in PCOS patients.

Methods: The present study examined hormone levels (progesterone, prolactin, luteinizing and follicle stimulation hormones (LH and FSH, respectively), antioxidant factors (catalase, glutathione-s- transferase), lipid profiles and zinc concentration of 50 Iraqi women patients' diagnosis with PCOS and 40 healthy women, divided in two age groups of 15-29 and 30-45 years. Body mass index was estimated for two age groups.

Results: The results showed decreasing of catalase, glutathione, and Zn concentrations with an increase in age. A slightly significant increase in LH and prolactin and decrease in high-density lipoprotein (HDL-C) with an increase in age in the patient group compared to the control group was noted.

Conclusion: Our study demonstrated that some factors (such as family history, genetics, environmental, etc…) could play a role in altering hormone levels, lipid profiles, and antioxidant. Controlling these factors may be useful for reducing the PCOS-associated problems in women's health. Needed extensive studies to assess the correlation with insulin resistant and obesity.

Keywords: Hormones disorders; Lipid profile; Polycystic ovary syndrome; Zinc element.

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Figures

Fig. 1
Fig. 1
Statistical analysis of the parameters for: a. Age group (15-29) yeas. b. Age group (30-45) years.
Fig. 2
Fig. 2
The correlation between Catalase and LH levels in PCOS groups using linear regression analysis (Pearson correlation).
Fig. 3
Fig. 3
The correlation between Cholesterol and FSH levels in PCOS groups using linear regression analysis (Pearson correlation).
See this image and copyright information in PMC

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