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Comparative Study
. 2021 May;163(5):1327-1333.
doi: 10.1007/s00701-021-04790-7. Epub 2021 Mar 2.

Comparison of clinical outcomes and accuracy of electrode placement between robot-assisted and conventional deep brain stimulation of the subthalamic nucleus: a single-center study

Shams Ribault  1   2 , Emile Simon  3   4 , Julien Berthiller  5 , Gustavo Polo  3 , Adélaïde Nunes  1 , Andrei Brinzeu  5 , Patrick Mertens  3   4 , Teodor Danaila  1 , Stéphane Thobois #  1   6   7 , Chloé Laurencin #  8   9
Affiliations
Comparative Study

Comparison of clinical outcomes and accuracy of electrode placement between robot-assisted and conventional deep brain stimulation of the subthalamic nucleus: a single-center study

Shams Ribault et al. Acta Neurochir (Wien). 2021 May.

Abstract

Background: Several surgical methods are used for deep brain stimulation (DBS) of the subthalamic nucleus (STN) in Parkinson's disease (PD). This study aimed to compare clinical outcomes and electrode placement accuracy after robot-assisted (RAS) versus frame-based stereotactic (FSS) STN DBS in Parkinson's disease.

Methods: In this single-center open-label study, we prospectively collected data from 48 consecutive PD patients who underwent RAS (Neuromate®; n = 20) or FSS (n = 28) STN DBS with the same MRI-based STN targeting between October 2016 and December 2018 in the university neurological hospital of Lyon, France. Clinical variables were assessed before and 1 year after surgery. The number of electrode contacts within the STN was determined by merging post-operative CT and pre-operative MRI using Brainlab® GUIDE™XT software.

Results: One year after surgery, the improvement of motor manifestations (p = 0.18), motor complications (p = 0.80), and quality of life (p= 0.30) and the reduction of dopaminergic treatment (p = 0.94) and the rate of complications (p = 0.99) were similar in the two groups. Surgery duration was longer in the RAS group (p = 0.0001). There was no difference in the number of electrode contacts within the STN.

Conclusion: This study demonstrates that RAS and FSS STN DBS for PD provide similar clinical outcomes and accuracy of electrode placement.

Keywords: Deep brain stimulation; Electrode placement; Parkinson’s disease; Robot-assisted surgery.

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References

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