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Review
. 2021 May;384(2):241-254.
doi: 10.1007/s00441-021-03419-6. Epub 2021 Mar 2.

Cell-based endometrial regeneration: current status and future perspectives

Neda Keyhanvar  1   2 , Nosratollah Zarghami  2 , Nathalie Bleisinger  3 , Hamed Hajipour  4   5 , Amir Fattahi  6   7 , Mohammad Nouri  8   9 , Ralf Dittrich  3
Affiliations
Review

Cell-based endometrial regeneration: current status and future perspectives

Neda Keyhanvar et al. Cell Tissue Res. 2021 May.

Abstract

Endometrial-related disorders including Asherman's syndrome, thin endometrium, pelvic organ prolapse, and cesarean scar pregnancies can be accompanied by different symptoms such as amenorrhea, infertility, abnormal placental implantation and recurrent miscarriage. Different methods have been introduced to overcome these problems such as surgery and hormonal therapy but none of them has shown promising outcomes. On the other hand, the development of novel regenerative therapeutic strategies has opened new avenues for the treatment of endometrial-related deficiencies. In this regard, different types of scaffolds, acellular matrices and also cell therapy with adult or stem cells have been investigated for the treatment of endometrial-related deficiencies. In this paper, we review the current status of cell-based endometrium regeneration using scaffold dependent and scaffold-free methods and future perspectives in this field. Moreover, we discuss the endometrial diseases that can be candidates for cell-based treatments. Also, the cells with the potential for endometrial regeneration are explained.

Keywords: Cell-based engineering; Endometrial disorders; Regeneration therapy; Scaffold.

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