Complex Interaction Among Immune, Inflammatory, and Carcinogenic Mechanisms in the Head and Neck Squamous Cell Carcinoma

doi:10.1007/5584_2021_626

. 2021:1335:11-35.

doi: 10.1007/5584_2021_626.

Complex Interaction Among Immune, Inflammatory, and Carcinogenic Mechanisms in the Head and Neck Squamous Cell Carcinoma

Ana Caruntu^{1

2}, Cristian Scheau³, Mircea Tampa^{4

5}, Simona Roxana Georgescu^{6

7}, Constantin Caruntu^{8

9}, Cristiana Tanase^{2

10}

Affiliations

¹ Department of Oral and Maxillofacial Surgery, "Carol Davila" Central Military Emergency Hospital, Bucharest, Romania.
² Faculty of Dental Medicine, "Titu Maiorescu" University, Bucharest, Romania.
³ Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
⁴ Department of Dermatology, "Victor Babes" Clinical Hospital for Infectious Diseases, Bucharest, Romania. tampa_mircea@yahoo.com.
⁵ Department of Dermatology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. tampa_mircea@yahoo.com.
⁶ Department of Dermatology, "Victor Babes" Clinical Hospital for Infectious Diseases, Bucharest, Romania.
⁷ Department of Dermatology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
⁸ Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. costin.caruntu@gmail.com.
⁹ Department of Dermatology, "Prof. N.C. Paulescu" National Institute of Diabetes, Nutrition, and Metabolic Diseases, Bucharest, Romania. costin.caruntu@gmail.com.
¹⁰ Department of Biochemistry-Proteomics, "Victor Babes" National Institute of Pathology, Bucharest, Romania.

PMID: 33650087
DOI: 10.1007/5584_2021_626

Complex Interaction Among Immune, Inflammatory, and Carcinogenic Mechanisms in the Head and Neck Squamous Cell Carcinoma

Ana Caruntu et al. Adv Exp Med Biol. 2021.

. 2021:1335:11-35.

doi: 10.1007/5584_2021_626.

Authors

Ana Caruntu^{1

2}, Cristian Scheau³, Mircea Tampa^{4

5}, Simona Roxana Georgescu^{6

7}, Constantin Caruntu^{8

9}, Cristiana Tanase^{2

10}

Affiliations

¹ Department of Oral and Maxillofacial Surgery, "Carol Davila" Central Military Emergency Hospital, Bucharest, Romania.
² Faculty of Dental Medicine, "Titu Maiorescu" University, Bucharest, Romania.
³ Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
⁴ Department of Dermatology, "Victor Babes" Clinical Hospital for Infectious Diseases, Bucharest, Romania. tampa_mircea@yahoo.com.
⁵ Department of Dermatology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. tampa_mircea@yahoo.com.
⁶ Department of Dermatology, "Victor Babes" Clinical Hospital for Infectious Diseases, Bucharest, Romania.
⁷ Department of Dermatology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
⁸ Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. costin.caruntu@gmail.com.
⁹ Department of Dermatology, "Prof. N.C. Paulescu" National Institute of Diabetes, Nutrition, and Metabolic Diseases, Bucharest, Romania. costin.caruntu@gmail.com.
¹⁰ Department of Biochemistry-Proteomics, "Victor Babes" National Institute of Pathology, Bucharest, Romania.

PMID: 33650087
DOI: 10.1007/5584_2021_626

Abstract

Inflammation is deeply involved in the development of most types of cancer. Many studies focus on the interaction between immune-inflammatory mechanisms and tumorigenesis in the head and neck squamous cell carcinoma (HNSCC). In this chapter, we emphasize the complexity of processes underlying this interaction and discuss the mechanisms of carcinogenesis in HNSCC with a special focus on metabolic changes, inflammation, and the immune landscape. Unveiling complex connections between immuno-inflammatory processes and tumor initiation, promotion, and progression will open new directions in the reliable identification of predictive factors and therapeutic targets in HNSCC.

Keywords: Cancer; Head and neck squamous cell carcinoma; Immunity; Inflammation; Therapy; Tumorigenesis.

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Cited by

Assessment of Histological Features in Squamous Cell Carcinoma Involving Head and Neck Skin and Mucosa.
Caruntu A, Moraru L, Lupu M, Ciubotaru DA, Dumitrescu M, Eftimie L, Hertzog R, Zurac S, Caruntu C, Voinea OC. Caruntu A, et al. J Clin Med. 2021 May 27;10(11):2343. doi: 10.3390/jcm10112343. J Clin Med. 2021. PMID: 34071843 Free PMC article.
Persistent Changes of Peripheral Blood Lymphocyte Subsets in Patients with Oral Squamous Cell Carcinoma.
Caruntu A, Moraru L, Surcel M, Munteanu A, Costache DO, Tanase C, Constantin C, Scheau C, Neagu M, Caruntu C. Caruntu A, et al. Healthcare (Basel). 2022 Feb 10;10(2):342. doi: 10.3390/healthcare10020342. Healthcare (Basel). 2022. PMID: 35206956 Free PMC article.
The Hidden Treasures of Preoperative Blood Assessment in Oral Cancer: A Potential Source of Biomarkers.
Caruntu A, Moraru L, Lupu M, Taubner L, Caruntu C, Tanase C. Caruntu A, et al. Cancers (Basel). 2021 Sep 5;13(17):4475. doi: 10.3390/cancers13174475. Cancers (Basel). 2021. PMID: 34503285 Free PMC article.
The Relationship between the Prognostic Marker LIMA1 in Head and Neck Squamous Cell Carcinoma and Immune Infiltration.
Huang H, Du Y, Zhao D, Chen K. Huang H, et al. J Oncol. 2022 Aug 31;2022:1040116. doi: 10.1155/2022/1040116. eCollection 2022. J Oncol. 2022. PMID: 37181789 Free PMC article.
The Assessment of Serum Cytokines in Oral Squamous Cell Carcinoma Patients: An Observational Prospective Controlled Study.
Caruntu A, Scheau C, Codrici E, Popescu ID, Calenic B, Caruntu C, Tanase C. Caruntu A, et al. J Clin Med. 2022 Sep 14;11(18):5398. doi: 10.3390/jcm11185398. J Clin Med. 2022. PMID: 36143043 Free PMC article.

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References

1. Aggarwal B, Sethi G, Nair A, Ichikawa H (2006) Nuclear factor-κB: a holy grail in cancer prevention and therapy. Curr Signal Transduction Ther 1(1):25–52
1. Alfred G, Knudson J (1971) Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A 68:820–823
1. Allin KH, Bojesen SE, Nordestgaard BG (2009) Baseline C-reactive protein is associated with incident cancer and survival in patients with cancer. J Clin Oncol 27(13):2217–2224
1. Alsaab HO, Sau S, Alzhrani R, Tatiparti K, Bhise K, Kashaw SK, Iyer AK (2017) PD-1 and PD-L1 checkpoint signaling inhibition for cancer immunotherapy: mechanism, combinations, and clinical outcome. Front Pharmacol 8:561
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[1] Aggarwal B, Sethi G, Nair A, Ichikawa H (2006) Nuclear factor-κB: a holy grail in cancer prevention and therapy. Curr Signal Transduction Ther 1(1):25–52

[2] Aggarwal B, Sethi G, Nair A, Ichikawa H (2006) Nuclear factor-κB: a holy grail in cancer prevention and therapy. Curr Signal Transduction Ther 1(1):25–52

[3] Alfred G, Knudson J (1971) Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A 68:820–823

[4] Alfred G, Knudson J (1971) Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A 68:820–823

[5] Allin KH, Bojesen SE, Nordestgaard BG (2009) Baseline C-reactive protein is associated with incident cancer and survival in patients with cancer. J Clin Oncol 27(13):2217–2224

[6] Allin KH, Bojesen SE, Nordestgaard BG (2009) Baseline C-reactive protein is associated with incident cancer and survival in patients with cancer. J Clin Oncol 27(13):2217–2224

[7] Alsaab HO, Sau S, Alzhrani R, Tatiparti K, Bhise K, Kashaw SK, Iyer AK (2017) PD-1 and PD-L1 checkpoint signaling inhibition for cancer immunotherapy: mechanism, combinations, and clinical outcome. Front Pharmacol 8:561

[8] Alsaab HO, Sau S, Alzhrani R, Tatiparti K, Bhise K, Kashaw SK, Iyer AK (2017) PD-1 and PD-L1 checkpoint signaling inhibition for cancer immunotherapy: mechanism, combinations, and clinical outcome. Front Pharmacol 8:561

[9] Alsibai KD, Meseure D (2018) Significance of tumor microenvironment scoring and immune biomarkers in patient stratification and cancer outcomes. In: Histopathology. IntechOpen, Rijeka. https://doi.org/10.5772/intechopen.72648. Accessed on 14 Jan 2021

[10] Alsibai KD, Meseure D (2018) Significance of tumor microenvironment scoring and immune biomarkers in patient stratification and cancer outcomes. In: Histopathology. IntechOpen, Rijeka. https://doi.org/10.5772/intechopen.72648. Accessed on 14 Jan 2021

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Complex Interaction Among Immune, Inflammatory, and Carcinogenic Mechanisms in the Head and Neck Squamous Cell Carcinoma

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Complex Interaction Among Immune, Inflammatory, and Carcinogenic Mechanisms in the Head and Neck Squamous Cell Carcinoma

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