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Review
. 2021 Nov-Dec;47(6):1120-1130.
doi: 10.1590/S1677-5538.IBJU.2020.0333.

Periodontal disease and the risk of prostate cancer: a meta-analysis of cohort studies

Zhenlang Guo  1 , Chiming Gu  1 , Siyi Li  1 , Shu Gan  1 , Yuan Li  1 , Songtao Xiang  1 , Leiliang Gong  2 , Shusheng Wang  1
Affiliations
Review

Periodontal disease and the risk of prostate cancer: a meta-analysis of cohort studies

Zhenlang Guo et al. Int Braz J Urol. 2021 Nov-Dec.

Abstract

Background: Periodontal disease is reportedly associated with the risk of various systemic diseases, including pancreatic and lung cancers. However, its association with prostate cancer remains inconclusive. Herein, we explored the association of periodontal disease with the risk of prostate cancer through a meta-analysis.

Materials and methods: MEDLINE, Embase, Web of Sciences and Cochrane Library databases were searched for eligible publications up to April 2020. Multivariate adjusted risk estimates with corresponding 95% confidence intervals (CIs) were extracted and calculated using random- or fixed-effect models.

Results: Nine cohort studies involving 3.353 prostate cancer cases with 440.911 participants were identified and included in the meta-analysis. We found that periodontal disease significantly increased the risk of prostate cancer by 1.40-fold (hazard ratio [HR]=1.40, 95% CI: 1.16-1.70; P=0.001; I2=76.1%) compared with normal condition. Interestingly, the risk of developing prostate cancer was not significant in patients treated with periodontal therapy (HR=1.22, 95% CI: 0.86-1.73; P=0.272; I2=65.2%). The results of subgroup analyses were also consistent and significant when stratified by study design and follow-up period, whereas conflicting results were observed in periodontal disease ascertainment stratification. These findings were robust as indicated by sensitivity analyses.

Conclusions: Periodontal disease was associated with the increased risk of prostate cancer, whereas no significant association was observed in patients treated with periodontal therapy. Hence, the awareness and importance for maintaining oral health should be improved, and the underlying mechanisms linking periodontal disease and prostate cancer should be fully explored in future research.

Keywords: Periodontal Diseases; Prostatic Neoplasms; Systematic Review [Publication Type].

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1. Flow diagram of literature searches according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.
Figure 2
Figure 2. Meta-analysis on association between periodontal disease and prostate cancer risk. CI, confidence interval, HR, Hazard Ratio.
See this image and copyright information in PMC

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