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Comparative Study
. 2021 Jul;24(4):926-936.
doi: 10.1007/s10120-021-01169-6. Epub 2021 Mar 2.

Is advanced esophageal adenocarcinoma a distinct entity from intestinal subtype gastric cancer? Data from the AGAMENON-SEOM Registry

Felipe Alvarez-Manceñido  1 , Paula Jimenez-Fonseca  2 , Alberto Carmona-Bayonas  3 , Virginia Arrazubi  4 , Raquel Hernandez  5 , Juana M Cano  6 , Ana Custodio  7 , Carles Pericay Pijaume  8 , Gema Aguado  9 , Nieves Martínez Lago  10 , Manuel Sánchez Cánovas  11 , Diego Cacho Lavin  12 , Laura Visa  13 , Alba Martinez-Torron  14 , Aranzazu Arias-Martinez  15 , Flora López  16 , M Luisa Limón  17 , Rosario Vidal Tocino  18 , Ana Fernández Montes  19 , Maria Alsina  20 , Paola Pimentel  21 , Pablo Reguera  22 , Alfonso Martín Carnicero  23 , Avinash Ramchandani  24 , Mónica Granja  25 , Aitor Azkarate  26 , Marta Martín Richard  27 , Olbia Serra  28 , Carolina Hernández Pérez  29 , Alicia Hurtado  30 , Aitziber Gil-Negrete  31 , Tamara Sauri  32 , Patricia Morales Del Burgo  33 , Javier Gallego  34
Affiliations
Comparative Study

Is advanced esophageal adenocarcinoma a distinct entity from intestinal subtype gastric cancer? Data from the AGAMENON-SEOM Registry

Felipe Alvarez-Manceñido et al. Gastric Cancer. 2021 Jul.

Abstract

Background: Advanced esophageal adenocarcinoma (EAC) is generally treated similarly to advanced gastroesophageal junction (GEJ-AC) and gastric (GAC) adenocarcinomas, although GAC clinical trials rarely include EAC. This work sought to compare clinical characteristics and treatment outcomes of advanced EAC with those of GEJ-AC and GAC and examine prognostic factors.

Patients and methods: Participants comprised patients with advanced EAC, intestinal GEJ-AC, and GAC treated with platin and fluoropyrimidine (plus trastuzumab when HER2 status was positive). Overall and progression-free survival were estimated using the Kaplan-Meier method. Cox proportional hazards regression gauged the prognostic value of the AGAMENON model.

Results: Between 2008 and 2019, 971 participants from the AGAMENON-SEOM registry were recruited at 35 centers. The sample included 67.3% GAC, 13.3% GEJ-AC, and 19.4% EAC. Pulmonary metastases were most common in EAC and peritoneal metastases in GAC. Median PFS and OS were 7.7 (95% CI 7.3-8.0) and 13.9 months (12.9-14.7). There was no difference in PFS or OS between HER2- and HER2+ tumors from the three locations (p > 0.05). Five covariates were found to be prognostic for the entire sample: ECOG-PS, histological grade, number of metastatic sites, NLR, and HER2+ tumors treated with trastuzumab. In EAC, the same variables were prognostic except for grade. The favorable prognosis for HER2+ cancers treated with trastuzumab was homogenous for all three subgroups (p = 0.351) and, after adjusting for the remaining covariates, no evidence supported primary tumor localization as a prognostic factor (p = 0.331).

Conclusion: Our study supports the hypothesis that EAC exhibits clinicopathological characteristics, prognostic factors, and treatment outcomes comparable to intestinal GEJ-AC and GAC.

Keywords: Advanced cancer; Chemotherapy; Erbb; Esophageal adenocarcinoma; Gastric cancer; Gastroesophageal junction; Lauren type; Prognosis; Survival; Trastuzumab.

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References

    1. Lordick F, Mariette C, Haustermans K, Obermannová R, Arnold D, On behalf of the ESMO Guidelines Committee clinicalguidelines@esmo org. Oesophageal cancer: ESMO clinical practice guidelines for diagnosis treatment and follow-up. Ann Oncol. 2016;27:50–7. - DOI
    1. Muro K, Lordick F, Tsushima T, Pentheroudakis G, Baba E, Lu Z, et al. Pan-Asian adapted ESMO Clinical Practice Guidelines for the management of patients with metastatic oesophageal cancer: a JSMO-ESMO initiative endorsed by CSCO, KSMO, MOS SSO and TOS. Ann Oncol. 2019;30:34–43. - DOI
    1. Ajani JA, D Amico TA, Bentrem DJ, Chao J, Corvera C, Das P, et al. NCCN Guidelines Version 3.2020 Gastric Cancer [Internet]. 2020.
    1. Martin-Richard M, Díaz Beveridge R, Arrazubi V, Alsina M, Galan Guzmán M, Custodio AB, et al. SEOM clinical guideline for the diagnosis and treatment of esophageal cancer (2016). Clin Transl Oncol. 2016;18:1179–86. - DOI
    1. Van Cutsem E, Moiseyenko VM, Tjulandin S, Majlis A, Constenla M, Boni C, et al. Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V25 study group. J Clin Oncol. 2006;24:4991–7. - DOI

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