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. 2021 Jan-Dec:27:1076029621999722.
doi: 10.1177/1076029621999722.

Serum Adenosine Deaminase as a Useful Marker to Estimate Coronary Artery Calcification in Type 2 Diabetes Mellitus Patients

Ming Yu  1 , Hanyun Zhou  2 , Qingan Li  1 , Juan Ding  3 , Hongxia Shuai  3 , Ji Zhang  4
Affiliations

Serum Adenosine Deaminase as a Useful Marker to Estimate Coronary Artery Calcification in Type 2 Diabetes Mellitus Patients

Ming Yu et al. Clin Appl Thromb Hemost. 2021 Jan-Dec.

Abstract

We investigated the association between serum adenosine deaminase and coronary artery calcification (CAC) in type 2 diabetes mellitus (T2DM) patients. The cross-sectional study included 459 patients with T2DM, the clinical and laboratory tests were performed, and all T2DM patients were separated into the 3 groups based on the tertile of serum adenosine deaminase levels. In the baseline data, the CAC score had statistically significant differences between the 3 groups (p < 0.001). Serum adenosine deaminase levels were positively correlated with CAC score in T2DM patients (r = 0.355, p < 0.001). The results of multiple linear regression analysis showed that serum adenosine deaminase was independent positively correlated with CAC score in T2DM patients (r = 0.255, p < 0.001). Receiver-operating characteristic curve analysis showed that area under curve was 0.750 to identify T2DM patients with CAC. Serum adenosine deaminase levels are correlated with CAC scores in T2DM patients, clinically, serum adenosine deaminase should be considered as an underlying marker to determine the severity of atherosclerosis in T2DM patients.

Keywords: cardiovascular disease; coronary artery calcification; serum adenosine deaminase; type 2 diabetes mellitus.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Receiver-operating characteristic curve analysis of serum adenosine deaminas in identifying T2DM patients with CAC.
See this image and copyright information in PMC

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