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. 2021 Jun:151:104870.
doi: 10.1016/j.fitote.2021.104870. Epub 2021 Feb 27.

Shanpanootols A-F, diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their Vpr inhibitory activities

Nwet Nwet Win  1 , Takeshi Kodama  1 , Zin Paing Htoo  1 , Saw Yu Yu Hnin  1 , Hla Ngwe  2 , Ikuro Abe  3 , Hiroyuki Morita  4
Affiliations

Shanpanootols A-F, diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their Vpr inhibitory activities

Nwet Nwet Win et al. Fitoterapia. 2021 Jun.

Abstract

Six new isopimarane diterpenoids, shanpanootols A-F (1-6), along with two known analogues, were isolated from the ethyl acetate-soluble extract of Kaempferia pulchra rhizomes collected in Myanmar. The structures of these compounds were elucidated by extensive spectroscopic techniques such as 1D and 2D NMR and HRESIMS. The absolute configuration of 1 was determined by the modified Mosher method. The new isolates (1-6) were tested for their Vpr inhibitory activities against TREx-HeLa-Vpr cells. Shanpanootols C (3) and E (5) inhibited Vpr at doses of 2.5 and 5 μM, respectively.

Keywords: Isopimarane diterpenoid; Kaempferia pulchra; Myanmar; Shanpanootols; Vpr.

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