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. 2021 Nov;35(11):3334-3338.
doi: 10.1038/s41375-021-01194-5. Epub 2021 Mar 2.

Enhanced thrombin/PAR1 activity promotes G-CSF- and AMD3100-induced mobilization of hematopoietic stem and progenitor cells via NO upregulation

Neta Nevo #  1 , Lizeth-Alejandra Ordonez-Moreno #  1 , Shiri Gur-Cohen  1 , Francesca Avemaria  1 , Suditi Bhattacharya  1 , Eman Khatib-Massalha  1 , Mayla Bertagna  1 , Montaser Haddad  1 , Priyasmita Chakrabarti  1 , Wolfram Ruf  2   3 , Tsvee Lapidot  4 , Orit Kollet  5
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Enhanced thrombin/PAR1 activity promotes G-CSF- and AMD3100-induced mobilization of hematopoietic stem and progenitor cells via NO upregulation

Neta Nevo et al. Leukemia. 2021 Nov.
No abstract available

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References

    1. Aronovich A, Nur Y, Shezen E, Rosen C, Zlotnikov Klionsky Y, Milman I, et al. A novel role for factor VIII and thrombin/PAR1 in regulating hematopoiesis and its interplay with the bone structure. Blood. 2013;122:2562–71. - DOI
    1. Borkowska S, Suszynska M, Mierzejewska K, Ismail A, Budkowska M, Salata D, et al. Novel evidence that crosstalk between the complement, coagulation and fibrinolysis proteolytic cascades is involved in mobilization of hematopoietic stem/progenitor cells (HSPCs). Leukemia. 2014;28:2148–54. - DOI
    1. Gur-Cohen S, Itkin T, Chakrabarty S, Graf C, Kollet O, Ludin A, et al. PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells. Nat Med. 2015;21:1307–17. - DOI
    1. Nevo N, Zuckerman T, Gur-Cohen S, Kollet O, Avemaria F, Shpall EJ, et al. PAR1 expression predicts clinical G-CSF CD34(+) HSPC mobilization and repopulation potential in transplanted patients. Hemasphere. 2019;3:e288. - DOI
    1. Nguyen TS, Lapidot T, Ruf W. Extravascular coagulation in hematopoietic stem and progenitor cell regulation. Blood. 2018;132:123–31. - DOI

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