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Comparative Study
. 1977 Nov;18(2):348-51.
doi: 10.1128/iai.18.2.348-351.1977.

Escherichia coli heat-labile enterotoxin: comparison of antitoxin assays and serum antitoxin levels

I K Wachsmuth, J G Wells, R W Ryder
Comparative Study

Escherichia coli heat-labile enterotoxin: comparison of antitoxin assays and serum antitoxin levels

I K Wachsmuth et al. Infect Immun. 1977 Nov.

Abstract

The mouse adrenal tumor cells (Y-1 strain) and the Chinese hamster ovary cells, two routinely used tissue culture assays for Escherichia coli heat-labile enterotoxin (LT), were used to detect serum antitoxin responses in culture-positive patients from several well-defined sources. There was no correlation between a significant antitoxin response and isolation of LT-producing E. coli in two "domestic" diarrheal outbreaks. Serum samples from a third group of individuals in a rural cholera-endemic area consistently demonstrated significant rises in neutralizing antibody to LT.

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References

    1. Lancet. 1976 Mar 27;1(7961):659-63 - PubMed
    1. Ann Intern Med. 1977 Jun;86(6):714-8 - PubMed
    1. J Infect Dis. 1977 May;135(5):720-8 - PubMed
    1. Infect Immun. 1974 Aug;10(2):320-7 - PubMed
    1. Infect Immun. 1974 Mar;9(3):564-70 - PubMed

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