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. 2021;34(2):253-261.
doi: 10.20524/aog.2020.0559. Epub 2020 Dec 7.

Acute biliary pancreatitis has better outcomes but increased resource utilization compared to acute alcohol-induced pancreatitis: insights from a nationwide study

Sachit Sharma  1 , Christian Nehme  1 , Muhammad Aziz  1 , Simcha Weissman  2 , Ahmad Khan  3 , Ashu Acharya  1 , Ishaan Vohra  4 , Sami Ghazaleh  1 , Ali Nawras  5 , Douglas G Adler  6
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Acute biliary pancreatitis has better outcomes but increased resource utilization compared to acute alcohol-induced pancreatitis: insights from a nationwide study

Sachit Sharma et al. Ann Gastroenterol. 2021.

Abstract

Background: The differences in outcomes between acute biliary pancreatitis (ABP) and acute alcohol-induced pancreatitis (AAP) have not been well studied. We sought to examine the differences between ABP and AAP as regards to in-hospital outcomes and resource utilization, using a large nationwide database.

Methods: We queried the National Inpatient Sample databases 2016 and 2017 using the International Classification of Diseases, 10th revision, Clinical Modification (ICD-10-CM) coding system to identify the patients with a primary diagnosis of AAP and ABP. The primary outcome was all-cause in-hospital mortality. Secondary outcomes were hospital length of stay (LOS), hospitalization charge/cost, shock, acute kidney injury (AKI), intensive care unit (ICU) admission, and home discharge. Analysis was performed with STATA software.

Results: There was no significant difference in mortality between patients with AAP and ABP (0.42% vs. 0.82%, adjusted odds ratio [aOR] 0.95, 95% confidence interval [CI] 0.69-1.31; P=0.79). Patients with ABP had a significantly longer LOS (+0.48 days, P<0.001). Patients with ABP had significantly higher adjusted mean hospitalization charges ($+19,958, P<0.001) and costs ($+4,848, P<0.001). Patients with ABP had a significantly lower likelihood of shock (aOR 0.75, 95%CI 0.59-0.95; P=0.02), AKI (aOR 0.76, 95%CI 0.71-0.82; P<0.001) or ICU admission (aOR 0.74, 95%CI 0.62-0.88; P=0.001). They were more likely to be discharged home (aOR 1.26, 95%CI 1.18-1.34; P<0.001).

Conclusion: Although there was no difference in all-cause mortality, patients with ABP had better hospitalization outcomes but greater resource utilization.

Keywords: Acute biliary pancreatitis; acute alcohol-induced pancreatitis; mortality; outcomes; resource utilization.

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Conflict of interest statement

Conflict of Interest: None

Figures

Figure 1
Figure 1
Patient selection flow diagram AP, acute pancreatitis
Figure 2
Figure 2
Etiology of acute pancreatitis in our National Inpatient Sample study
See this image and copyright information in PMC

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