COVID-19 cytokine storm syndrome: a threshold concept

doi:10.1016/S2666-5247(20)30223-8

. 2021 Feb;2(2):e49-e50.

doi: 10.1016/S2666-5247(20)30223-8. Epub 2021 Feb 2.

COVID-19 cytokine storm syndrome: a threshold concept

Luke Y C Chen^{1

2}, Tien T T Quach²

Affiliations

¹ Division of Hematology, University of British Columbia, Vancouver, BC V5Z1M9, Canada.
² Centre for Health Education Scholarship, University of British Columbia, Vancouver, BC V5Z1M9, Canada.

PMID: 33655230
PMCID: PMC7906728
DOI: 10.1016/S2666-5247(20)30223-8

COVID-19 cytokine storm syndrome: a threshold concept

Luke Y C Chen et al. Lancet Microbe. 2021 Feb.

. 2021 Feb;2(2):e49-e50.

doi: 10.1016/S2666-5247(20)30223-8. Epub 2021 Feb 2.

Authors

Luke Y C Chen^{1

2}, Tien T T Quach²

Affiliations

¹ Division of Hematology, University of British Columbia, Vancouver, BC V5Z1M9, Canada.
² Centre for Health Education Scholarship, University of British Columbia, Vancouver, BC V5Z1M9, Canada.

PMID: 33655230
PMCID: PMC7906728
DOI: 10.1016/S2666-5247(20)30223-8

No abstract available

PubMed Disclaimer

Cited by

Inflammation and Venous Thromboembolism in Hospitalized Patients with COVID-19.
Liontos A, Biros D, Matzaras R, Tsarapatsani KH, Kolios NG, Zarachi A, Tatsis K, Pappa C, Nasiou M, Pargana E, Tsiakas I, Lymperatou D, Filippas-Ntekouan S, Athanasiou L, Samanidou V, Konstantopoulou R, Vagias I, Panteli A, Milionis H, Christaki E. Liontos A, et al. Diagnostics (Basel). 2023 Nov 19;13(22):3477. doi: 10.3390/diagnostics13223477. Diagnostics (Basel). 2023. PMID: 37998613 Free PMC article.
The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication.
Ning Q, Wu D, Wang X, Xi D, Chen T, Chen G, Wang H, Lu H, Wang M, Zhu L, Hu J, Liu T, Ma K, Han M, Luo X. Ning Q, et al. Signal Transduct Target Ther. 2022 Feb 23;7(1):57. doi: 10.1038/s41392-022-00907-1. Signal Transduct Target Ther. 2022. PMID: 35197452 Free PMC article. Review.
Advances in Understanding Long COVID: Pathophysiological Mechanisms and the Role of Omics Technologies in Biomarker Identification.
da Silva MD, da Silva TS, Mendes CG, Valbão MCM, Badu-Tawiah AK, Laurindo LF, Barbalho SM, Direito R, Miglino MA. da Silva MD, et al. Mol Diagn Ther. 2025 Jun 18. doi: 10.1007/s40291-025-00792-8. Online ahead of print. Mol Diagn Ther. 2025. PMID: 40531392 Review.
Mechanism for the attenuation of neutrophil and complement hyperactivity by MSC exosomes.
Loh JT, Zhang B, Teo JKH, Lai RC, Choo ABH, Lam KP, Lim SK. Loh JT, et al. Cytotherapy. 2022 Jul;24(7):711-719. doi: 10.1016/j.jcyt.2021.12.003. Epub 2022 Feb 15. Cytotherapy. 2022. PMID: 35177337 Free PMC article.
Diabetes, Metformin and the Clinical Course of Covid-19: Outcomes, Mechanisms and Suggestions on the Therapeutic Use of Metformin.
Bailey CJ, Gwilt M. Bailey CJ, et al. Front Pharmacol. 2022 Mar 9;13:784459. doi: 10.3389/fphar.2022.784459. eCollection 2022. Front Pharmacol. 2022. PMID: 35370738 Free PMC article. Review.

See all "Cited by" articles

References

1. Awdish RLA. The liminal space. N Engl J Med. 2020;383:e17. - PubMed
1. England JT, Abdulla A, Biggs CM. Weathering the COVID-19 storm: lessons from hematologic cytokine syndromes. Blood Rev. 2020 doi: 10.1016/j.blre.2020.100707. published online May 15. - DOI - PMC - PubMed
1. Leisman DE, Ronner L, Pinotti R. Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes. Lancet Respir Med. 2020;8:1233–1244. - PMC - PubMed
1. Chen LYC, Hoiland RL, Stukas S, Wellington CL, Sekhon MS. Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome. Eur Respir J. 2020;56 - PMC - PubMed
1. Webb BJ, Peltan ID, Jensen P. Clinical criteria for COVID-19-associated hyperinflammatory syndrome: a cohort study. Lancet Rheumatol. 2020;2:e754–e763. - PMC - PubMed

MeSH terms

Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information

[1] Awdish RLA. The liminal space. N Engl J Med. 2020;383:e17. - PubMed

[2] Awdish RLA. The liminal space. N Engl J Med. 2020;383:e17. - PubMed

[3] England JT, Abdulla A, Biggs CM. Weathering the COVID-19 storm: lessons from hematologic cytokine syndromes. Blood Rev. 2020 doi: 10.1016/j.blre.2020.100707. published online May 15. - DOI - PMC - PubMed

[4] England JT, Abdulla A, Biggs CM. Weathering the COVID-19 storm: lessons from hematologic cytokine syndromes. Blood Rev. 2020 doi: 10.1016/j.blre.2020.100707. published online May 15. - DOI - PMC - PubMed

[5] Leisman DE, Ronner L, Pinotti R. Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes. Lancet Respir Med. 2020;8:1233–1244. - PMC - PubMed

[6] Leisman DE, Ronner L, Pinotti R. Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes. Lancet Respir Med. 2020;8:1233–1244. - PMC - PubMed

[7] Chen LYC, Hoiland RL, Stukas S, Wellington CL, Sekhon MS. Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome. Eur Respir J. 2020;56 - PMC - PubMed

[8] Chen LYC, Hoiland RL, Stukas S, Wellington CL, Sekhon MS. Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome. Eur Respir J. 2020;56 - PMC - PubMed

[9] Webb BJ, Peltan ID, Jensen P. Clinical criteria for COVID-19-associated hyperinflammatory syndrome: a cohort study. Lancet Rheumatol. 2020;2:e754–e763. - PMC - PubMed

[10] Webb BJ, Peltan ID, Jensen P. Clinical criteria for COVID-19-associated hyperinflammatory syndrome: a cohort study. Lancet Rheumatol. 2020;2:e754–e763. - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

COVID-19 cytokine storm syndrome: a threshold concept

Affiliations

COVID-19 cytokine storm syndrome: a threshold concept

Authors

Affiliations

Similar articles

Cited by

References

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical