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. 2021 Feb 26;36(3):e360301.
doi: 10.1590/ACB360301. eCollection 2021.

Light-emitting diode stimulates radiodermatitis recovery

Cristina Pires Camargo  1 , Heloisa Andrade Carvalho  2 , Feres Camargo Maluf  3 , Alexandre Agostinho da Cruz Sousa  4 , Paulo Otavio Maluf Perin  3 , Marcela Maluf Perin  5 , Julio Morais-Besteiro  1 , Rolf Gemperli  6
Affiliations

Light-emitting diode stimulates radiodermatitis recovery

Cristina Pires Camargo et al. Acta Cir Bras. .

Abstract

Purpose: To evaluate the effect of light-emitting diode (LED) in an experimental model of radiodermatitis.

Methods: Ten male Wistar rats weighing 200-250 g were analyzed. Radiation was delivered in a single dose (20 Gy with Strontium-90 dermatological plaques), two areas per animal. After 15 days, they were divided into two groups: control group (n = 5) and LED group (n = 5), which was treated during 21 days later (LED 660 nm, 10 min in alternate days). The endpoints were radiodermatitis scale, histological analysis HE, Picrius Sirius and the gene expression of interleukin-10 (IL-10) and matrix metalloproteinase-9 (MMP-9).

Results: The LED group showed a higher number of dermal appendages (p = 0.04) and angiogenesis(p = 0.007), a tendency towards higher IL-10 (p = 0.06) and an increase in MMP-9 (p = 0.004) when compared to the control group.

Conclusions: This study suggested that the use of LED for radiodermatitis increased skin regeneration.

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Conflict of interest statement

Conflict of interest: Nothing to declare.

Figures

Figure 1
Figure 1. Macroscopic aspect of radiodermatitis. (a) Control – pretreatment (RTOG scale score 5). (b) control – post-treatment (RTOG scale score 4.5). (c) LED – pretreatment (RTOG scale score 5), (d) LED = light-post-treatment (RTOG scale score 1)
Figure 2
Figure 2. Hematoxylin-eosin staining. (a) LED group, (b) control group. The LED treatment showed a high number of arterioles (angiogenesis) and dermal appendages when comparing to the control group.
Figure 3
Figure 3. Picrius Sirius staining. (a) LED group, (b) Control group. The LED treatment group treated with LED showed an increase in young type collagen (fine fibers) compared to the control group.
See this image and copyright information in PMC

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