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. 2021 Feb 24;47(2):e20200166.
doi: 10.36416/1806-3756/e20200166. eCollection 2021.

Cystic fibrosis-related mortality trends in Brazil for the 1999-2017 period: a multiple-cause-of-death study

[Article in English, Portuguese]
Augusto Hasiak Santo  1 , Luiz Vicente Ribeiro Ferreira da Silva-Filho  2   3
Affiliations

Cystic fibrosis-related mortality trends in Brazil for the 1999-2017 period: a multiple-cause-of-death study

[Article in English, Portuguese]
Augusto Hasiak Santo et al. J Bras Pneumol. .

Abstract
in English, Portuguese

Objective: To describe causes of death and mortality data related to cystic fibrosis (CF) using a multiple-cause-of-death methodology.

Methods: Annual mortality data for the 1999-2017 period were extracted from the Brazilian National Ministry of Health Mortality Database. All death certificates in which category E84 (CF) of the ICD-10, was listed as an underlying or associated cause of death were selected. Epidemiological and clinical data were described, and standardized mortality rates were calculated per year and for the 2000-2017 period. A joinpoint regression analysis was performed to detect changes in the mortality rates during the study period.

Results: Overall, 2,854 CF-related deaths were identified during the study period, ranging from 68 in 1999 to 289 in 2017. CF was the underlying cause of death in 83.5% of the death certificates. A continuous upward trend in the death rates was observed, with a significant annual percent change of 6.84% (5.3-8.4%) among males and 7.50% (6.6-8.4%) among females. The median age at death increased from 7.5 years in 1999 to 56.5 years in 2017. Diseases of the respiratory system accounted for 77% of the associated causes in the death certificates that reported CF as the underlying cause of death.

Conclusions: A significant and continuous increase in CF-related death rates was found in Brazil in the last years, as well as a concurrent increase in the median age at death.

Objetivo:: Descrever as causas de morte e dados sobre mortalidade relacionada à fibrose cística (FC) por meio da metodologia de causas múltiplas de morte.

Métodos:: Dados sobre a mortalidade anual no período de 1999 a 2017 foram extraídos do Sistema de Informações sobre Mortalidade do Ministério da Saúde do Brasil. Foram selecionadas todas as declarações de óbito em que a categoria E84 (FC) da CID-10 foi citada como causa básica ou associada de morte. Foram descritos os dados epidemiológicos e clínicos e calculadas as taxas padronizadas de mortalidade por ano e para o período de 2000 a 2017. Foi realizada a análise de regressão por pontos de inflexão para detectar mudanças nas taxas de mortalidade durante o período estudado.

Resultados:: No total, foram identificadas 2.854 mortes relacionadas à FC durante o período de estudo: de 68 em 1999 a 289 em 2017. A FC foi a causa básica de morte em 83,5% das declarações de óbito. Observou-se uma tendência contínua de aumento das taxas de mortalidade, com variação percentual anual significativa de 6,84% (5,3-8,4%) nos homens e de 7,50% (6,6-8,4%) nas mulheres. A mediana da idade de óbito aumentou de 7,5 anos em 1999 para 56,5 anos em 2017. As doenças do aparelho respiratório representaram 77% das causas associadas nas declarações de óbito em que a FC foi a causa básica de morte.

Conclusões:: Observou-se no Brasil um aumento significativo e contínuo das taxas de mortalidade relacionada à FC nos últimos anos, bem como um aumento concomitante da mediana da idade de óbito.

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Figures

Figure 1
Figure 1. Medians and interquartile ranges of age at death related to cystic fibrosis according to the regions in Brazil, 1999-2007.
Figure 2
Figure 2. Age-standardized death rates related to cystic fibrosis according to sex. Brazil, 2000-2017.
Figure 3
Figure 3. Trends in median age at death related to cystic fibrosis according to sex. Brazil, 1999-2017.
See this image and copyright information in PMC

Comment in

  • Cystic fibrosis in Brazil: achievements in survival.
    Vendrusculo FM, Donadio MVF, Pinto LA. Vendrusculo FM, et al. J Bras Pneumol. 2021 Apr 30;47(2):e20210140. doi: 10.36416/1806-3756/e20210140. J Bras Pneumol. 2021. PMID: 33950101 Free PMC article. No abstract available.

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