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. 2021 May 3;218(5):e20210281.
doi: 10.1084/jem.20210281.

Immunodominant antibody germlines in COVID-19

Emanuele Andreano  1 , Rino Rappuoli  1   2
Affiliations

Immunodominant antibody germlines in COVID-19

Emanuele Andreano et al. J Exp Med. .

Abstract

The neutralizing antibody response to SARS-CoV-2 is dominated by antibodies deriving from germlines IGHV3-53/IGHV3-66, which are also associated with self-reacting antibodies. Could vaccines avoid the expansion of this immunodominant response, decrease the risk of autoimmunity, and still protect against emerging SARS-CoV-2 variants?

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Figures

Figure 1.
Figure 1.
The cryptic role of IGHV3-53 and IGHV3-66 antibodies in COVID-19. Summary of the roles of two predominant antibody germlines elicited by COVID-19 infection. (A–C) The figure shows different functions of IGHV3-53 and IGHV3-66 antibodies after infection which are virus neutralization (A), evolution of escape variants (B), and possible autoimmunity (C).
See this image and copyright information in PMC

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