Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2021:1321:309-324.
doi: 10.1007/978-3-030-59261-5_28.

Acute Kidney Injury and Covid-19: A Scoping Review and Meta-Analysis

Mehdi Jafari-Oori  1 , Marco Fiorentino  2 , Giuseppe Castellano  3 , Abbas Ebadi  4 , Farshid Rahimi-Bashar  5 , Paul C Guest  6 , Amir Vahedian-Azimi  7 , Amirhossein Sahebkar  8   9   10   11
Affiliations
Meta-Analysis

Acute Kidney Injury and Covid-19: A Scoping Review and Meta-Analysis

Mehdi Jafari-Oori et al. Adv Exp Med Biol. 2021.

Abstract

Acute kidney injury (AKI) is a fatal complication of the new severe acute respiratory syndrome coronavirus (SARS-CoV-2) which causes COVID-19 disease. Here, we performed a scoping review and meta-analysis including clinical studies on patients with SARS-CoV-2 infection with data on AKI assessment and characteristics, and the overall prevalence of AKI was estimated using a random-effects model. We identified 21 articles which passed the search criteria. All were quantitative observational studies which used a cross-sectional, retrospective, case report, or cohort methodology. This showed that aging, diabetes, cardiovascular disease, previous chronic disease, and other comorbidities were risk factors of AKI. Although the prevalence of proteinuria, hematuria, and increased serum creatinine was reported for up to 60% of the patients with COVID-19, the overall prevalence of AKI was estimated to be 8%. We conclude that although approximately two-thirds of patients with COVID-19 had symptoms of kidney damage, most of these did not meet the diagnostic criteria for AKI. Further studies should be performed to validate biomarkers for improved AKI diagnosis in COVID-19 patients and new treatment options are required to reduce the rate of mortality.

Keywords: Acute kidney injury; COVID-19; Meta-analysis; Scoping review.

PubMed Disclaimer

References

    1. Lu H, Stratton CW, Tang YW (2020) Outbreak of pneumonia of unknown etiology in Wuhan, China: the mystery and the miracle. J Med Virol 92(4):401–402 - DOI
    1. World Health Organization (2020) Novel coronavirus (2019-nCoV) situation report – 1, 21 Jan 2020. https://www.who.int/docs/default-source/coronaviruse/situation-reports/2...
    1. Chu KH, Tsang WK, Tang CS, Lam MF, Lai FM, To KF et al (2005) Acute renal impairment in coronavirus-associated severe acute respiratory syndrome. Kidney Int 67(2):698–705 - DOI
    1. ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E et al (2012) Acute respiratory distress syndrome: the Berlin Definition. JAMA 307(23):2526–2533
    1. Perico L, Benigni A, Remuzzi G (2020) Should COVID-19 concern nephrologists? Why and to what extent? The emerging impasse of angiotensin blockade. Nephron 144(5):213–221 - DOI

LinkOut - more resources