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Review
. 2021 Jun;9(2):340-350.
doi: 10.1002/iid3.416. Epub 2021 Mar 3.

Current research status of HLA in immune-related diseases

Bingnan Liu  1 , Yuanyuan Shao  1 , Rong Fu  1
Affiliations
Review

Current research status of HLA in immune-related diseases

Bingnan Liu et al. Immun Inflamm Dis. 2021 Jun.

Abstract

Human leukocyte antigen (HLA), also known as human major histocompatibility complex (MHC), is encoded by the HLA gene complex, and is currently known to have the highest gene density and the most polymorphisms among human chromosomal areas. HLA is divided into class I antigens, class II antigens, and class III antigens according to distribution and function. Classical HLA class I antigens include HLA-A, HLA-B, and HLA-C; HLA class II antigens include HLA-DP, HLA-DQ, and HLA-DR; nonclassical HLA class I and II molecules include HLA-F, E, H, X, DN, DO, and DM; and others, such as complement, are class III antigens. HLA is closely related to the body's immune response, regulation, and surveillance and is of great significance in the study of autoimmune diseases, tumor immunity, organ transplantation, and reproductive immunity. HLA is an important research topic that bridges immunology and clinical diseases. With the development of research methods and technologies, there will be more discoveries and broader prospects.

Keywords: HLA; MHC; immune-related diseases.

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References

    1. Trowsdale J, Knight JC. Major histocompatibility complex genomics and human disease. Annu Rev Genomics Hum Genet. 2013;14:301‐323. - PMC - PubMed
    1. van Drongelen V, Holoshitz J. Human leukocyte antigen‐disease associations in rheumatoid arthritis. Rheum Dis Clin North Am. 2017;43(3):363‐376. - PMC - PubMed
    1. El‐Awar N, Jucaud V, Nguyen A, Epitopes HLA. The targets of monoclonal and alloantibodies defined. J Immunol Res. 2017;2017:3406230. - PMC - PubMed
    1. Busch R, Kollnberger S, Mellins ED. HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications. Nat Rev Rheumatol. 2019;15(6):364‐381. - PubMed
    1. Katagiri T, Sato‐Otsubo A, Kashiwase K, et al. Marrow donor, frequent loss of HLA alleles associated with copy number‐neutral 6pLOH in acquired aplastic anemia. Blood. 2011;118(25):6601‐6609. - PubMed

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