Comment

. 2021 Mar 2;33(3):455-456.

doi: 10.1016/j.cmet.2021.02.012.

Treatment regimens may compromise gut-microbiome-derived signatures for liver cirrhosis

Sicheng Wu¹, Puzi Jiang¹, Xing-Ming Zhao², Wei-Hua Chen³

Affiliations

¹ Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular Imaging, Center for Artificial Intelligence Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan, Hubei, China.
² Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, 200433 Shanghai, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Ministry of Education, Shanghai 200433, China; Research Institute of Intelligent Complex System, Fudan University, Shanghai 200433, China. Electronic address: xmzhao@fudan.edu.cn.
³ Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular Imaging, Center for Artificial Intelligence Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan, Hubei, China; College of Life Science, HeNan Normal University, 453007 Xinxiang, Henan, China. Electronic address: weihuachen@hust.edu.cn.

PMID: 33657385
DOI: 10.1016/j.cmet.2021.02.012

Free article

Comment

Treatment regimens may compromise gut-microbiome-derived signatures for liver cirrhosis

Sicheng Wu et al. Cell Metab. 2021.

Free article

. 2021 Mar 2;33(3):455-456.

doi: 10.1016/j.cmet.2021.02.012.

Authors

Sicheng Wu¹, Puzi Jiang¹, Xing-Ming Zhao², Wei-Hua Chen³

Affiliations

¹ Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular Imaging, Center for Artificial Intelligence Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan, Hubei, China.
² Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, 200433 Shanghai, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Ministry of Education, Shanghai 200433, China; Research Institute of Intelligent Complex System, Fudan University, Shanghai 200433, China. Electronic address: xmzhao@fudan.edu.cn.
³ Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular Imaging, Center for Artificial Intelligence Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, 430074 Wuhan, Hubei, China; College of Life Science, HeNan Normal University, 453007 Xinxiang, Henan, China. Electronic address: weihuachen@hust.edu.cn.

PMID: 33657385
DOI: 10.1016/j.cmet.2021.02.012

Abstract

Many of the gut-microbiome-derived signatures for liver cirrhosis, especially the important ones, were likely under the influence of proton pump inhibitors (PPIs). Wu et al. suggest that drug usage is a confounding factor in metagenomics analysis that should be controlled for.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment in

Proton pump inhibitor use status does not modify the microbiome signature for cirrhosis.
Oh TG, Kim SM, Atkins AR, Yu RT, Downes M, Evans RM, Loomba R. Oh TG, et al. Cell Metab. 2021 Mar 2;33(3):457. doi: 10.1016/j.cmet.2021.02.013. Cell Metab. 2021. PMID: 33657386

Comment on

A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis.
Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin CB, Downes M, Evans RM, Loomba R. Oh TG, et al. Cell Metab. 2020 Nov 3;32(5):878-888.e6. doi: 10.1016/j.cmet.2020.06.005. Epub 2020 Jun 30. Cell Metab. 2020. PMID: 32610095 Free PMC article.

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Treatment regimens may compromise gut-microbiome-derived signatures for liver cirrhosis

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Treatment regimens may compromise gut-microbiome-derived signatures for liver cirrhosis

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