Proton pump inhibitor use status does not modify the microbiome signature for cirrhosis

Tae Gyu Oh¹, Susy M Kim², Annette R Atkins¹, Ruth T Yu¹, Michael Downes¹, Ronald M Evans³, Rohit Loomba⁴

Affiliations

¹ Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
² NAFLD Research Center, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
³ Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: evans@salk.edu.
⁴ NAFLD Research Center, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: roloomba@ucsd.edu.

PMID: 33657386
DOI: 10.1016/j.cmet.2021.02.013

Free article

Comment

Proton pump inhibitor use status does not modify the microbiome signature for cirrhosis

Tae Gyu Oh et al. Cell Metab. 2021.

Free article

. 2021 Mar 2;33(3):457.

doi: 10.1016/j.cmet.2021.02.013.

Authors

Tae Gyu Oh¹, Susy M Kim², Annette R Atkins¹, Ruth T Yu¹, Michael Downes¹, Ronald M Evans³, Rohit Loomba⁴

Affiliations

¹ Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
² NAFLD Research Center, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
³ Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: evans@salk.edu.
⁴ NAFLD Research Center, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: roloomba@ucsd.edu.

PMID: 33657386
DOI: 10.1016/j.cmet.2021.02.013

Abstract

Oh et al. address concerns about the influence of proton pump inhibitor (PPI) use on a gut microbiome signature for cirrhosis. By removing PPI using subjects from the training cohort and retraining a 19-species Random Forest model, they demonstrate the impact of PPI usage on the signature's diagnostic accuracy is minimal.

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Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest.

Comment on

A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis.
Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T, Brenner DA, Sirlin CB, Downes M, Evans RM, Loomba R. Oh TG, et al. Cell Metab. 2020 Nov 3;32(5):878-888.e6. doi: 10.1016/j.cmet.2020.06.005. Epub 2020 Jun 30. Cell Metab. 2020. PMID: 32610095 Free PMC article.
Treatment regimens may compromise gut-microbiome-derived signatures for liver cirrhosis.
Wu S, Jiang P, Zhao XM, Chen WH. Wu S, et al. Cell Metab. 2021 Mar 2;33(3):455-456. doi: 10.1016/j.cmet.2021.02.012. Cell Metab. 2021. PMID: 33657385

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Proton pump inhibitor use status does not modify the microbiome signature for cirrhosis

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Proton pump inhibitor use status does not modify the microbiome signature for cirrhosis

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Conflict of interest statement

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