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Comment
. 2021 Mar 2;33(3):462-463.
doi: 10.1016/j.cmet.2021.02.011.

How does obesity promote breast cancer tumor growth?

Marc L Reitman  1
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Free article
Comment

How does obesity promote breast cancer tumor growth?

Marc L Reitman. Cell Metab. .
Free article

Abstract

Obesity is a risk factor for many cancers. Maguire et al. (2021) found increased creatine synthesis by the adipocytes adjacent to breast cancers in obese mice. The creatine is transported into the cancer cells, producing larger tumors, possibly due to greater energy availability.

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Conflict of interest statement

Declaration of Interests The author declares no competing interests.

Comment on

  • Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer.
    Maguire OA, Ackerman SE, Szwed SK, Maganti AV, Marchildon F, Huang X, Kramer DJ, Rosas-Villegas A, Gelfer RG, Turner LE, Ceballos V, Hejazi A, Samborska B, Rahbani JF, Dykstra CB, Annis MG, Luo JD, Carroll TS, Jiang CS, Dannenberg AJ, Siegel PM, Tersey SA, Mirmira RG, Kazak L, Cohen P. Maguire OA, et al. Cell Metab. 2021 Mar 2;33(3):499-512.e6. doi: 10.1016/j.cmet.2021.01.018. Epub 2021 Feb 16. Cell Metab. 2021. PMID: 33596409 Free PMC article.

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