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Comment
. 2021 Mar 2;33(3):468-470.
doi: 10.1016/j.cmet.2021.02.004.

Keep your macrophages fit for healthy aging

Jan Van den Bossche  1 , Pieter J M Leenen  2
Affiliations
Free article
Comment

Keep your macrophages fit for healthy aging

Jan Van den Bossche et al. Cell Metab. .
Free article

Abstract

As age is the greatest risk factor for the development of most prevalent chronic diseases, there is an enormous interest in understanding the process of aging, with the hope of delaying or preventing age-related comorbidities. Along these lines, a recent study by Minhas et al. (2021) describes how aged macrophages downregulate glycolysis and mitochondrial oxidative phosphorylation (OXPHOS), inducing an energy-deficient state that compromises macrophage function and supports maladaptive inflammation that together cause brain dysfunction.

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Conflict of interest statement

Declaration of Interests The authors declare no competing interests.

Comment on

  • Restoring metabolism of myeloid cells reverses cognitive decline in ageing.
    Minhas PS, Latif-Hernandez A, McReynolds MR, Durairaj AS, Wang Q, Rubin A, Joshi AU, He JQ, Gauba E, Liu L, Wang C, Linde M, Sugiura Y, Moon PK, Majeti R, Suematsu M, Mochly-Rosen D, Weissman IL, Longo FM, Rabinowitz JD, Andreasson KI. Minhas PS, et al. Nature. 2021 Feb;590(7844):122-128. doi: 10.1038/s41586-020-03160-0. Epub 2021 Jan 20. Nature. 2021. PMID: 33473210 Free PMC article.

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