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Comment
. 2021 Mar 2;33(3):470-472.
doi: 10.1016/j.cmet.2021.02.010.

Mitochondrial dysfunction defines T cell exhaustion

Gonzalo Soto-Heredero  1 , Gabriela Desdín-Micó  1 , María Mittelbrunn  2
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Comment

Mitochondrial dysfunction defines T cell exhaustion

Gonzalo Soto-Heredero et al. Cell Metab. .
Free article

Abstract

When T cells are exposed to continuous antigen stimulation, they become exhausted. Here, we preview findings from Scharping et al. (2021), who have illuminated the molecular mechanism by which the persistent antigen stimulation and severe hypoxic conditions in the intratumoral environment drive T cell exhaustion, losing their cytotoxic function and anticancer effects.

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Conflict of interest statement

Declaration of Interests The authors declare no competing interests.

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