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. 2021 Feb 15:10:618564.
doi: 10.3389/fonc.2020.618564. eCollection 2020.

The Role of Postoperative Radiotherapy and Prognostic Model in Primary Squamous Cell Carcinoma of Parotid Gland

Wenlong Qiu  1 , Yong Yang  1 , Shiran Sun  1 , Fengge Zhou  1 , Yi Xu  1 , Xi Luo  1 , Zekun Wang  1 , Meilin He  1 , Yang Liu  1 , Junlin Yi  1
Affiliations

The Role of Postoperative Radiotherapy and Prognostic Model in Primary Squamous Cell Carcinoma of Parotid Gland

Wenlong Qiu et al. Front Oncol. .

Abstract

Background: Primary squamous cell carcinoma of parotid gland (parotid SCC) is a high malignant histologic subtype of parotid cancers with aggressive clinical presentation. However, the clinical features and survival benefit of postoperative radiotherapy (PORT) for primary parotid SCC are not well known.

Methods: A retrospective population-based study was performed to identify the role of PORT in parotid SCC patients diagnosed between 1975 and 2016 from SEER database. A prognostic risk model was established based on patient clinical features, including age, tumor stage, and node involvement status. Patients were stratified into high, intermediate, and low risk according to this model. The survival benefit of radiotherapy was compared in the whole cohort and different risk groups.

Results: Nine hundred thirty-one parotid SCC patients were extracted from SEER database, 634 (68.1%) in the RT group and 286 (30.7%) in the non-RT group. Overall, 503 (54.0%) deaths occurred, with a median follow-up of 84 months, the 5-year OS was 43.6% in the whole cohort, 47.7 vs 35.9% in patients with/without PORT (P = 0.005), and 58.9 vs. 38.8 vs. 27.1% in low-, intermediate-, and high-risk group (P < 0.001). Compared with surgery alone, PORT significantly improved the OS of patients with medium risk (47.5 vs. 20.6, P < 0.001), whereas not in the low risk (61 vs. 54%, P = 0.710) and high (25.6 vs. 28.7%, P = 0.524).

Conclusion: This prognostic model can separate the patients with parotid squamous cell carcinoma into different risk. PORT significantly improved the OS of patients with intermediate risk, whereas high-risk group may need more intensive treatment strategies.

Keywords: parotid gland; prognostic risk; radiotherapy; squamous cell carcinoma; surgery.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow chart for the creation of the patient cohort data set.
Figure 2
Figure 2
The overall survival of patients with squamous cell carcinoma of the parotid gland is illustrated according to the accept of radiotherapy (Surveillance, Epidemiology, and End Results registries, 1975–2016).
Figure 3
Figure 3
The overall survival of patients with squamous cell carcinoma of the parotid gland is illustrated according to (A) prognostic risk score and (B) prognostic risk stratification.
Figure 4
Figure 4
The median survival, 5-year OS, and hazard ratio comparing the overall survival (OS) between radiotherapy (RT) group and non-RT group according to (A) prognostic risk score and (B) prognostic risk stratification. HR, hazard ratio; CI, confidence interval.
See this image and copyright information in PMC

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