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Review
. 2020 Nov 19:9:16.
doi: 10.12703/b/9-16. eCollection 2020.

Recent advances in tendinopathy

Dimitris Challoumas  1   2 , Mairiosa Biddle  2 , Neal L Millar  1   2
Affiliations
Review

Recent advances in tendinopathy

Dimitris Challoumas et al. Fac Rev. .

Abstract

Tendinopathy refers to the clinical diagnosis of activity-related pain resulting in a decline in tendon function. In the last few years, much has been published concerning the basic science and clinical investigation of tendinopathy and debates and discussions to new questions and points of view started many years ago. This advances review will discuss the current thinking on the basic science and clinical management of tendinopathy and in particular new findings in the tendon repair space that are relevant to the pathophysiology of tendinopathy. We will further discuss potential novel therapies on the horizon in human tendon disease.

Keywords: Tendon; pathogenesis; tendinopathy; tendon injury; tendon repair.

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Conflict of interest statement

The authors declare that they have no competing interests.No competing interests were disclosed.No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. Pathogenesis of tendinopathy.
Various risk factors including mechanical overuse, environmental factors including smoking, metabolic disease (diabetes, hyperlipidaemia), and genetics have been implicated in tendinopathy. Additionally, certain medications (fluoroquinolones, statins, excess corticosteroids), neuropathic mediators, excessive apoptosis, dysregulated molecular inflammation, and matrix production are all implicated in the development of tendinopathy. MMP, matrix metalloproteinase; TIMP, tissue inhibitors of metalloproteinases.
See this image and copyright information in PMC

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