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Review
. 2021 Aug;109(2):113-120.
doi: 10.1007/s00223-021-00828-1. Epub 2021 Mar 3.

Mitochondria Homeostasis and Vascular Medial Calcification

Min Li  1 , Yi Zhu  1 , Sandip Kumar Jaiswal  2 , Nai-Feng Liu  3
Affiliations
Review

Mitochondria Homeostasis and Vascular Medial Calcification

Min Li et al. Calcif Tissue Int. 2021 Aug.

Abstract

Vascular calcification occurs highly prevalent, which commonly predicts adverse cardiovascular events. The pathogenesis of calcification, a complicated and multifactorial process, is incompletely characterized. Accumulating evidence shows that mitochondrial dysfunction may ultimately be more detrimental in the vascular smooth muscle cells (VSMCs) calcification. This review summarizes the role of mitochondrial dysfunction and metabolic reprogramming in vascular calcification, and indicates that metabolic regulation may be a therapeutic target in vascular calcification.

Keywords: Glucose metabolism; Mitochondria; VSMCs; Vascular calcification.

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