Not Only Preterm Neonates Mature but Also Traditional Dosing Regimens Have to Mature: The Role of Mathematical Modeling

Gilbert Koch¹, John N van den Anker^{2

3

4}

Affiliations

¹ Paediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel, University of Basel, Basel, Switzerland.
² Paediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel, University of Basel, Basel, Switzerland, jvandena@cnmc.org.
³ Division of Clinical Pharmacology, Children's National Hospital, Washington, District of Columbia, USA, jvandena@cnmc.org.
⁴ Intensive Care and Department of Pediatric Surgery, Erasmus MC/Sophia Children's Hospital, Rotterdam, The Netherlands, jvandena@cnmc.org.

Comment

Gilbert Koch et al. Neonatology. 2021.

. 2021;118(1):114-115.

doi: 10.1159/000513750. Epub 2021 Mar 4.

Gilbert Koch¹, John N van den Anker^{2

3

4}

¹ Paediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel, University of Basel, Basel, Switzerland.
² Paediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel, University of Basel, Basel, Switzerland, jvandena@cnmc.org.
³ Division of Clinical Pharmacology, Children's National Hospital, Washington, District of Columbia, USA, jvandena@cnmc.org.
⁴ Intensive Care and Department of Pediatric Surgery, Erasmus MC/Sophia Children's Hospital, Rotterdam, The Netherlands, jvandena@cnmc.org.

No abstract available

Comment on

The Pharmacokinetics of Caffeine in Preterm Newborns: No Influence of Doxapram but Important Maturation with Age.
Engbers AGJ, Völler S, Poets CF, Knibbe CAJ, Reiss IKM, Koch BCP, Flint RB, Simons SHP. Engbers AGJ, et al. Neonatology. 2021;118(1):106-113. doi: 10.1159/000513413. Epub 2021 Feb 24. Neonatology. 2021. PMID: 33626528