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. 2021 Mar 4;11(1):5174.
doi: 10.1038/s41598-021-84866-7.

Postoperative around-the-clock administration of intravenous acetaminophen for pain control following robot-assisted radical prostatectomy

Shogo Inoue  1 , Hirotsugu Miyoshi  2 , Keisuke Hieda  3 , Tetsutaro Hayashi  3 , Yasuo M Tsutsumi  2 , Jun Teishima  3
Affiliations

Postoperative around-the-clock administration of intravenous acetaminophen for pain control following robot-assisted radical prostatectomy

Shogo Inoue et al. Sci Rep. .

Abstract

The objective of this study was to examine the impact of around-the-clock (ATC) administration of intravenous (IV) acetaminophen following robot-assisted radical prostatectomy (RARP). Intravenous infusion of acetaminophen was started on the day of the operation at 1000 mg/dose every 6 h, and the infusion was continued on a fixed schedule until postoperative day 2 a.m. In a retrospective observational study, we compared 127 patients who were administered IV acetaminophen on a fixed schedule (ATC group) with 485 patients who were administered analgesic drugs only as needed (PRN group). We investigated postoperative pain intensity and additional analgesic consumption on postoperative day 0, 1, 2, 3, and 5 between the two groups. Postoperative pain scores were significantly lower in the ATC group than in the PRN group at 1 and 2 days, and this period matched the duration of ATC administration of IV acetaminophen. Postoperative frequency of rescue analgesia was significantly lower in the ATC group than in the PRN group at postoperative 0, 1, and 2 days. ATC administration of IV acetaminophen has the potential to be a very versatile and valuable additional dose to achieve appropriate postoperative analgesia in patients with RARP.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Flowchart for study inclusion among patients with localized PCa who had undergone RARP. PCEA patient-controlled epidural analgesia, RARP robot-assisted radical prostatectomy, ADT androgen deprivation therapy, CKD chronic kidney disease, ATC around-the-clock, PRN pro re nata, PCa prostate cancer.
Figure 2
Figure 2
Comparison of postoperative pain scores after surgery. ATC around-the-clock, PRN pro re nata, *p < 0.05 versus baseline value.
Figure 3
Figure 3
Comparison of frequency of rescue analgesia after surgery. ATC around-the-clock, PRN pro re nata, *p < 0.05 versus baseline value.
Figure 4
Figure 4
Comparison of catheter related bladder discomfort after surgery. ATC around-the-clock, PRN pro re nata, *p < 0.05 versus baseline value.
See this image and copyright information in PMC

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