Pharmacokinetics of benperidol in volunteers after oral administration
Affiliations
- PMID: 3366499
Item in Clipboard
Pharmacokinetics of benperidol in volunteers after oral administration
Int J Clin Pharmacol Res.
1988.
Abstract
Benperidol in a 4 mg single dose was administered orally to five healthy male volunteers. The drug was rapidly absorbed (tmax = 2.27 +/- 0.57 h) and largely distributed, the volume of distribution being 5.19 +/- 1.99 l.kg-1. Elimination half-life was 7.65 +/- 2.14 h. Urinary excretion represented only a minimal fraction of ingested dose (0.1 +/- 0.007%). Variability of the area under the curve makes a first-pass metabolism a reasonable possibility. Acute dystonias appeared in two subjects.
Similar articles
-
Pharmacokinetics and bioavailability of benperidol in schizophrenic patients after intravenous and two different kinds of oral application.Psychopharmacology (Berl). 1994 Dec;116(4):457-63. doi: 10.1007/BF02247478. Psychopharmacology (Berl). 1994. PMID: 7701049 Clinical Trial.
-
Disposition and miotic effects of oral alfentanil: a potential noninvasive probe for first-pass cytochrome P4503A activity.Clin Pharmacol Ther. 2003 Mar;73(3):199-208. doi: 10.1067/mcp.2003.30. Clin Pharmacol Ther. 2003. PMID: 12621385
-
Pharmacokinetics and pharmacodynamics of tolterodine in man: a new drug for the treatment of urinary bladder overactivity.Int J Clin Pharmacol Ther. 1997 Jul;35(7):287-95. Int J Clin Pharmacol Ther. 1997. PMID: 9247842 Clinical Trial.
-
Clinical pharmacokinetic of celecoxib in healthy Thai volunteers.J Med Assoc Thai. 2005 May;88(5):632-8. J Med Assoc Thai. 2005. PMID: 16149679 Clinical Trial.
-
Buccal delivery of an alpha 2-adrenergic receptor antagonist, atipamezole, in humans.Clin Pharmacol Ther. 1995 Nov;58(5):506-11. doi: 10.1016/0009-9236(95)90170-1. Clin Pharmacol Ther. 1995. PMID: 7586944 Clinical Trial.
Cited by
-
Pharmacokinetics and bioavailability of benperidol in schizophrenic patients after intravenous and two different kinds of oral application.Psychopharmacology (Berl). 1994 Dec;116(4):457-63. doi: 10.1007/BF02247478. Psychopharmacology (Berl). 1994. PMID: 7701049 Clinical Trial.